维持性血液透析病人骨骼肌减少症发生率和危险因素研究

发布时间：2018-03-25 00:23

本文选题：维持性血液透析　切入点：骨骼肌减少症　出处：《肠外与肠内营养》2017年02期

【摘要】：目的:研究骨骼肌减少症在维持性血液透析(MHD)病人中的发生率和影响因素。方法:选取规律血液透析且病情稳定的131例非住院MHD病人,采用生物电阻抗法(BIA)测定病人的肌肉质量,并计算骨骼肌质量指数,测定病人的握力,用改良量化主观整体评估(MQSGA)法评估病人的营养状况,同时检测相关实验室指标,采用Logstic回归分析MHD病人肌少症的相关危险因素。结果:在131例MHD病人中,肌少症的发生率为41.22%(54/131),有或无肌少症两组间性别、透析时间、超敏C反应蛋白(hs-CRP)、MQSGA得分差异有显著性统计学意义(P0.05)。Logstic回归分析显示,男性肌少症发生率是女性的43.67倍,随着hs-CRP水平升高和MQSGA得分增加,肌少症的发生风险明显增加,差异有显著性统计学意义(P0.05)。结论:MHD病人肌少症的发生率高,男性、微炎症状态和营养不良是发生肌少症的危险因素。
[Abstract]:Objective: to study the incidence and influencing factors of skeletal myopenia in patients with maintenance hemodialysis (HD). Methods: 131 non-hospitalized MHD patients with regular hemodialysis and stable condition were selected. The muscle mass of patients was measured by bioelectric impedance method (BIA), and skeletal muscle mass index was calculated. The grip strength of patients was measured. The nutritional status of patients was evaluated by modified quantitative subjective integral evaluation (MQSGA) method. Logstic regression analysis was used to analyze the risk factors of hypomyopathy in MHD patients. Results: the incidence of hypomyopathy in 131 MHD patients was 41.22 / 54 / 131. The sex and dialysis time of the two groups with or without hypomyosis were 41.22 / 54 / 131, respectively. Significant statistical significance was found in the scores of hypersensitive C-reactive protein (hs-CRP) MQSGA. Logistic regression analysis showed that the incidence of hypomyopathy in males was 43.67 times higher than that in females. With the increase of hs-CRP level and MQSGA score, the risk of hypomyopathy increased significantly. Conclusion the incidence of hypothyroidism in patients with MHD is higher than that in male patients, and microinflammation and malnutrition are the risk factors of hypomyopathy.
【作者单位】：昆明医科大学第一附属医院肾内科;云南肾脏病医院肾内科;昆明医科大学第一附属医院临床营养科;
【基金】：云南省教育厅科学研究基金重大专项(ZD2014006) 云南省科技厅-昆明医科大学应用基础研究联合专项(面上项目)(2013FB038)
【分类号】：R459.5;R685

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