磁共振扩散加权成像在评估肠道克罗恩病病变活动性中的应用

发布时间：2018-04-22 10:41

本文选题：克罗恩病 + Harvey-Bradshow指数　；参考：《临床放射学杂志》2017年01期

【摘要】：目的探讨MRI定量参数测量表观扩散系数(ADC)在评估肠道克罗恩病(CD)病变活动性中的应用价值。方法对2014年6月至2016年1月间本院42例回盲部单发病灶的CD患者行扩散加权成像(DWI)扫描,测量ADC值,同时收集临床数据,Harvey-Bradshow指数(HBI)。(1)评估不同测量者之间ADC数据的可靠性与重复性;(2)将42例CD患者病变肠壁的ADC值与各自相应的HBI作相关分析;(3)根据HBI指数将42例CD患者分为重度活动组、轻中度活动组及静止组,比较三组间ADC值差异性。结果病变肠壁的ADC值可信度高(Cronbach's Alpha信度系数=0.961);ADC值与HBI呈负相关(r=-0.721,P0.001);静止组和轻中度活动组之间ADC有统计学差异(P0.001),静止组和重度活动组之间ADC有统计学差异(P0.001),轻中度活动组和重度活动组之间ADC有统计学差异(P0.001)。结论磁共振定量参数ADC具有较高的可信度,能够反映CD活动状态,具有临床应用价值。
[Abstract]:Objective to evaluate the value of MRI quantitative parameter scale (MRI) in evaluating the activity of intestinal Crohn's disease (CDD). Methods from June 2014 to January 2016, 42 CD patients with single ileocecal lesions were examined by diffusion weighted imaging (DWI) and their ADC values were measured. To evaluate the reliability and repeatability of ADC data between different measurements, the ADC value of intestinal wall of 42 patients with CD and their respective HBI were analyzed by correlation analysis according to HBI index. 42 patients with CD were analyzed according to HBI index. Divided into heavy activity groups, The differences of ADC between mild and moderate activity group and static group were compared. Results the reliability of Cronbachus Alpha Alpha was negatively correlated with HBI, and there was significant difference in ADC between quiescent group and mild to moderate active group (P 0.001), and between static group and severe active group (P 0.001). There was a significant difference in ADC between active group and severe active group (P 0.001). Conclusion quantitative magnetic resonance (ADC) parameters have high reliability and can reflect the active state of CD and have clinical application value.
【作者单位】：南京医科大学第二附属医院放射科;南京医科大学第二附属医院肠病中心;通用电气药业(上海)有限公司;
【分类号】：R445.2;R574.62

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