第三方脐血输注不良反应现状及其影响因素研究

发布时间：2019-04-12 09:49

【摘要】：目的探讨第三方脐血输注中不良反应的发生现状及其相关因素。方法 2013年1月—2015年12月,调查苏州市某三级甲等医院血液造血干细胞移植中心成功实施单倍体造血干细胞移植联合第三方脐血输注的305例恶性血液病患者,采用一般资料调查表及第三方脐血输注不良反应调查表收集资料。结果第三方脐血输注中不良反应发生率为49.51%,以心血管系统不良反应为主(82.78%),其中高血压发生率最高,为77.48%。引起不良反应发生的主要原因为年龄、脐血供受体人类白细胞抗原配型相合度、复苏脐血细胞活力。结论临床护理人员应对年龄较大,脐血供受体人类白细胞抗原配型相合度低,输注复苏脐血细胞活力高的单倍体造血干细胞移植联合第三方脐血输注的患者在干细胞输注期间加强监护,及时给予预见性护理。
[Abstract]:Objective To study the occurrence and related factors of the adverse reaction of third-party cord blood transfusion. Methods From January 2013 to December 2015, the successful implementation of the Haematopoietic Stem Cell Transplantation (HSCT) in a third class of Class A hospitals in Suzhou, and 305 patients with malignant hemopathy, which were infused with the third-party cord blood, were successfully implemented. The general data questionnaire and the third-party umbilical cord blood transfusion adverse reaction questionnaire were used to collect the data. Results The incidence of adverse reaction in the third-party cord blood transfusion was 49.51%, and the adverse reaction of the cardiovascular system was the main (82.78%), among which the highest incidence of hypertension was 77.48%. The main cause of the occurrence of the adverse reaction is age, the matching degree of the human leukocyte antigen matching of the umbilical blood supply receptor, and the vitality of the umbilical blood cells. Conclusion The clinical nursing staff should be able to strengthen the monitoring during the infusion of stem cells with the combination of the high degree of age, the low matching degree of the human leukocyte antigen matching of the umbilical blood supply receptor, the transfer of the haploid hemopoietic stem cell with the high vitality of the umbilical blood cell of the umbilical cord and the infusion of the cord blood of the third-party cord blood. Timely delivery of predictive care.
【作者单位】：苏州大学附属第一医院血液科;
【基金】：国家高科技研究计划(2012AA02A505)
【分类号】：R473.73

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