NK和iNKT细胞的转录调控研究

发布时间：2021-06-25 10:38

　　Natural killer（NK）cells are innate lymphoid cells widely recognized as important effectors during antiviral and anti-tumor responses.T-bet and Eomes are two transcription factors from the T-box family that are homologous with each other for protein sequence and DNA binding preferences.Both factors were previously shown to regulate NK cell development,but how they work together remains unclear.In this study,we identified complementary roles of Eomes and T-bet in the control of gene expression dur... 

【文章来源】：华东师范大学上海市 211工程院校 985工程院校 教育部直属院校

【文章页数】：255 页

【学位级别】：博士

【文章目录】：
abstract
Résumé
Acknowledgement
List of abbreviations
1 Natural Killer Cells
    1.1 Development
        1.1.1 Commitment to becoming a killer
        1.1.2 Making a mature killer
        1.1.3 Dispatching killers to the frontline
    1.2 NK Cell Surface Receptors
        1.2.1 Inhibitory receptors
        1.2.2 Activating receptors
        1.2.3 Cytokine receptors
        1.2.4 Chemotactic receptors
        1.2.5 Adhesion receptors
    1.3 NK Cell Education
    1.4 NK Cell Function
        1.4.1 Killer’s weapon:cytolysis
        1.4.2 Killer’s weapon:cytokine secretion
    1.5 NK Cell Memory
2 Transcription Factors Important for NK cell Development and Function
    2.1 Generalities on Transcription Factors
    2.2 Ets-family:Ets-1,PU.1,and Mef
    2.3 Nfil3
    2.4 Id2 and E-box proteins
    2.5 T-box Family:T-bet and Eomes
        2.5.1 The T-box family of transcription factors
        2.5.2 T-bet and Eomes in NK cells
    2.6 Zeb family transcription factors:Zeb1,Zeb2
    2.7 Runx proteins:Runx3
    2.8 Gata proteins:Gata3
    2.9 Blimp1
    2.10 Other TFs
3 NK-like Immune Cells or NK Paralogues
    3.1 CD8~+Cytotoxic T cells
    3.2 Innate Lymphoid Cells(ILCs)
        3.2.1 ILC1 cells
        3.2.2 ILC2 cells
        3.2.3 ILC3 cells
        3.2.4 LTi cells
    3.3 iNKT
        3.3.1 Development of iNKT cells
        3.3.2 Function of iNKT cells
        3.3.3 Transcriptional regulation of iNKT cell development and function
    3.4 NK1.1~+γδT cells
4 Research projects
    4.1 Scientific context and objectives
    4.2 Project1:T-bet and Eomes in NK cell development
        4.2.1 Article1
    4.3 Project2:Zeb1 in iNKT cell development.
        4.3.1 Article2
        4.3.2 Extended results
5 Discussion
    5.1 Project1:T-bet and Eomes in NK cell development
        5.1.1 Eomes and tissue-residency
        5.1.2 Eomes,T-bet and CD11b,CD27
        5.1.3 T-box family and proliferation
        5.1.4 T-box family and cytokine signaling
        5.1.5 Working model of T-bet and Eomes actions
    5.2 Project2:Zeb1 in iNKT cell development
        5.2.1 Cellophane and Zeb1~(?13/+)mice
        5.2.2 Splenomegaly,fibrosis and ILCs
        5.2.3 Zeb1 and lymphoma
        5.2.4 Zeb1 and E-proteins
        5.2.5 Zeb1 and iNKT cells
6 Conclusion and perspectives
    6.1 Conclusion
    6.2 Perspectives
References
Annex



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