乙醇和相关物质分析方法以及乙醇代谢动力学影响因素的研究

发布时间：2018-03-07 16:07

本文选题：乙醇　切入点：代谢动力学　出处：《四川大学》2005年硕士论文　论文类型：学位论文

【摘要】：乙醇(alcohol)俗称酒精,是酒精饮料的主要成分,是世界范围内被普遍滥用的一种物质。过量饮酒对中枢神经系统、心脑血管、消化系统、周围神经末梢都有损伤,可导致精神障碍、心衰、中毒性脑病、肝病(包括乙醇肝、脂肪肝、肝硬化)及多发性神经炎等。过量饮酒也可能会引起行为异常,导致意外甚至犯罪,比如车祸、吸入呕吐物窒息而死、酒后肇事等。很多情况下都需对血液中乙醇浓度(blood alcohol concentration, BAC)进行检测,并以BAC检测结果作为正确处理与乙醇有关的事(案)件的主要依据。饮酒后BAC与乙醇代谢动力学密切相关,以往有学者试图揭示出普遍适用的乙醇代谢动力学规律,并由此来推测饮酒个体某一时刻的BAC,或根据BAC推测实际饮酒量。但实际上乙醇代谢动力学受饮酒方式、饮酒的种类、饮酒时所吃的食物种类以及肝酶活性等多种因素的影响。此类问题受到众多学者的关注,而有关这方面的研究又少见报道。本研究希望通过实验建立一个可适应多种情况下的检测乙醇的方法,并运用所建立的方法检测志愿者在不同研究条件下饮酒后不同时刻的BAC,由此研究酒的种类、饮酒时间及不同饮酒个体对乙醇代谢动力学的影响,为进一步揭示乙醇代谢动力学规律提供基础研究资料。在检测BAC的实际工作中,会遇到各种各样的检材,检材中除含有我们感兴趣的目标化合物乙醇而外,可能同时还包含其他一些物质,如乙醛、
[Abstract]:Alcohol alcohol) commonly known as alcohol, is the main component of alcoholic beverages and is a substance commonly abused worldwide. Excessive drinking has damage to the central nervous system, cardiovascular and cerebrovascular systems, the digestive system, and the peripheral nerve endings, which can lead to mental disorders. Heart failure, toxic encephalopathy, liver disease (including ethanol liver, fatty liver, liver cirrhosis) and polyneuritis. Excessive drinking can also lead to behavioral abnormalities, accidents and even crimes, such as car accidents, suffocation of vomit, and death. A drunken accident, etc. In many cases, the concentration of ethanol in blood alcohol concentration (BACC) should be measured, and the results of BAC are used as the main basis for correct handling of ethanol-related matters. After drinking, BAC is closely related to the kinetics of ethanol metabolism. In the past, some scholars tried to reveal the universally applicable kinetic law of alcohol metabolism, and then speculated on the individual's drinking amount at a certain time, or according to BAC, but in fact, the alcohol metabolism kinetics was influenced by the drinking mode and the type of alcohol consumption. The variety of food consumed and the activity of liver enzymes have been affected by many factors, such as the type of food consumed, and the activity of liver enzymes, which have attracted the attention of many scholars. This study hopes to establish an experimental method for the detection of ethanol in a variety of situations. The BACs of volunteers at different time after drinking under different research conditions were detected by using the established method. The effects of alcohol types, drinking time and individual alcohol consumption on the kinetics of ethanol metabolism were studied. In order to further reveal the kinetics of ethanol metabolism to provide basic research data. In the actual work of detecting BAC, there will be a variety of samples, which may also contain some other substances, such as acetaldehyde, in addition to ethanol, which is the target compound of interest to us.
【学位授予单位】：四川大学
【学位级别】：硕士
【学位授予年份】：2005
【分类号】：D919

【引证文献】