吗啡在慢性染毒大鼠体内死后再分布

发布时间：2018-04-28 00:16

本文选题：慢性吗啡中毒 + 死后再分布　；参考：《西安交通大学学报(医学版)》2004年01期

【摘要】：目的　研究吗啡在慢性染毒大鼠体内的死后再分布特性。方法　在室温条件下 ,将对吗啡形成依赖的大鼠处死 ,分别在死亡当时和死后 2 4、48、72、96h采集心血及心肌、脑、肝、肾、肺组织 ,用固相萃取气相色谱法 (SPE GC)检测吗啡含量。结果　除肺外 ,心血和各组织吗啡含量在大鼠死后 96h内有不同程度增加。肝增加幅度最大 ,肾在 72～ 96h呈现下降 ,心肌在 2 4h有所下降 ,以后逐渐上升。各组织与死亡当时心血中吗啡含量相比 ,在大鼠死后 96h内脑中吗啡含量与其相差最小。结论　吗啡在慢性染毒大鼠体内存在死后再分布现象 ,脑组织能较好反映死亡当时心血中的吗啡含量
[Abstract]:Objective to study the postmortem redistribution of morphine in chronic exposed rats. Methods the morphine-dependent rats were killed at room temperature. The heart blood, heart blood, brain, liver, kidney and lung tissue were collected at the time of death and 24 minutes after death. The content of morphine was determined by solid phase extraction gas chromatography (SPE GC). Results except lung, morphine content in heart blood and tissues increased in varying degrees within 96 hours after death. The increase of liver was the largest, the kidney decreased at 72 ~ 96 h, the myocardium decreased at 24 h, and then increased gradually. The content of morphine in the brain of the rats at the time of death was the least than that in the heart blood at the time of death. Conclusion there is postmortem redistribution of morphine in chronic poisoned rats, and brain tissue can better reflect the morphine content in heart blood at the time of death.
【作者单位】：西安交通大学医学院法医系法医毒理教研室西安交通大学成人教育学院西安市公安局刑侦局技术处法化科西安交通大学医学院法医系法医毒理教研室西安交通大学医学院法医系法医毒理教研室
【分类号】：D919.4

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