大肠癌发病规律的统计学研究

发布时间：2018-08-14 09:22

【摘要】：大肠癌作为最常见的恶性肿瘤,其发病率及致死率一直是居高不下的。随着人们生活水平的日益提高,其发病率仍有逐年升高的趋势,严重威胁了人类的生命安全。本文主要应用统计学的方法将大肠癌患者的病理学参数指标进行分析,来探讨大肠癌的发病规律,以期为日后对大肠癌的研究与临床治疗起到一定的参考价值。文章在分析大肠癌发病规律时总要分为两个部分,一部分为对一般规律的分析,另一部分为对大肠癌淋巴结转移相关因素的分析。根据所选取变量的不同类型,主要采用四种分析方法,即相关分析、方差分析、对数线性模型分析及logistic回归分析。对于第一部分,主要通过图形及表格的形式将某个或某几个变量之间的相互作用关系直观的表示出来,从而寻找大肠癌的发病规律。在进行二分类logistic回归分析时,首先对各个变量进行单因素分析,然后将具有统计学意义的变量带入模型中再进行回归分析。经过对模型的诊断与修正,得到最终各临床及病理因素与淋巴结转移的关系的结果。本文的第一部分介绍了目前对大肠癌研究的现状及论文的背景和意义。第二部分主要就分析中使用的模型及方法从理论上进行论述。第三部分根据辽宁省人民医院近年来大肠癌病患的相关临床及病理资料进行具体分析并得出有参考性的结论。第四部分主要就前文内容进行总结及展望。
[Abstract]:Colorectal cancer as the most common malignant tumor, its incidence and mortality has been high. With the improvement of people's living standard, the incidence rate is still increasing year by year, which seriously threatens the safety of human life. This article mainly uses the statistical method to analyze the pathological parameters of patients with colorectal cancer, to explore the pathogenesis of colorectal cancer, in order to play a certain reference value for the future research and clinical treatment of colorectal cancer. In this paper, there are two parts to analyze the pathogenesis of colorectal cancer, one is to analyze the general law, the other is to analyze the factors related to lymph node metastasis of colorectal cancer. According to the different types of variables selected, four analytical methods are mainly used, namely, correlation analysis, variance analysis, logarithmic linear model analysis and logistic regression analysis. For the first part, the interaction relationship between one or a few variables is expressed intuitively by the form of graph and table, so as to find the law of the occurrence of colorectal cancer. In the two-classification logistic regression analysis, the single factor analysis of each variable is carried out first, and then the statistically significant variables are introduced into the model and then the regression analysis is carried out. The relationship between clinical and pathological factors and lymph node metastasis was obtained through the diagnosis and correction of the model. The first part of this paper introduces the current status of colorectal cancer research and the background and significance of the paper. The second part mainly discusses the models and methods used in the analysis. The third part analyzes the clinical and pathological data of colorectal cancer patients in Liaoning Provincial people's Hospital in recent years and draws some useful conclusions. The fourth part mainly summarizes and looks forward to the previous contents.
【学位授予单位】：东北大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R735.34;C81

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