婴幼儿喂养行为与其贫血关系的出生队列研究

发布时间：2017-12-27 02:34

本文关键词：婴幼儿喂养行为与其贫血关系的出生队列研究　出处：《浙江大学》2017年硕士论文　论文类型：学位论文

【摘要】：不少研究证实婴幼儿的喂养行为如全母乳喂养时间长短,辅食添加年龄与其血红蛋白浓度和贫血患病风险紧密相关。不过这些研究得出的结果并不一致,而且大部分研究都是在西方或欧洲国家进行的。因此需要更多的大型前瞻性研究,特别是在亚洲国家进行的研究,来进一步阐明这一关键问题。本研究的主要目的是基于我国的一个大型出生队列研究——嘉兴出生队列来探究婴儿全母乳喂养时长、辅食添加时间及种类与其贫血间的关系。本研究从嘉兴出生队列研究入手,从中筛选出提供了基本信息、详细母乳喂养和辅食添加信息以及其他一些测量学数据的婴儿。采用logistic回归模型来评估全母乳喂养时长、辅食添加时间与婴幼儿在12月龄和48-71月龄时贫血患病风险的关系;采用线性回归模型来衡量这两个因素与婴幼儿血红蛋白浓度的关系。本研究主要结果如下:(1)在探究全母乳喂养时长与贫血关系的研究中,共有25,393名婴儿纳入12月龄的分析,32,658名幼儿纳入48-71月龄的分析。分析发现与小于3个月的全母乳喂养相比,多6个月的全母乳喂养与婴儿在12月龄时的贫血患病风险增加显著相关,校正OR值为1.15(95%CI:1.02,1.29),在48-71月龄时仅为边缘显著相关,校正OR值为1.13(95%CI:0.99,1.29)。不过,不管是12月龄的婴儿还是48-71月龄的幼儿,≥6个月的全母乳喂养均与血红蛋白浓度的降低显著相关。(2)在探究辅食添加时间及种类与贫血关系的研究中,共有18,446名48-71月龄幼儿纳入分析。分析发现与在6月龄及以后添加辅食相比,在3-6月龄添加辅食与贫血风险增加显著相关,校正OR值为1.14(95%CI:1.01-1.28);与血红蛋白浓度降低也显著相关,校正平均差为-0.84g/L(95%CI:-1.33,-0.35)。在不同类别的辅食中,这种相关关系主要存在于植物性辅食如面包/烤馒头/挂面,烂面/饼干,豆腐等。综上所述,全母乳喂养时间过长(≥6个月)或添加辅食过早(3-6月龄时添加)均与婴幼儿贫血风险的增加以及血红蛋白浓度的降低有关。这与WHO现行推荐的在婴儿前6个月进行全母乳喂养,在6月龄时添加辅食相一致。因此,在进行6个月的全母乳喂养后,父母应注意给其孩子补充充足的铁来源来预防贫血的发生。
[Abstract]:Many studies confirm that infant feeding behavior is like breastfeeding time. The age of complementary feeding is closely related to the hemoglobin concentration and the risk of anemia. However, the results of these studies are not consistent, and most of the studies are conducted in Western or European countries. Therefore, more large prospective studies, especially in Asian countries, are needed to further clarify this key issue. The purpose of this study is based on a large birth cohort study in Jiaxing, the birth cohort in China, to explore the relationship between the duration of infant breastfeeding, the time and type of complementary food and its anemia. From the birth cohort study in Jiaxing, we screened out infants who provided basic information, detailed information about breastfeeding and complementary feeding, and some other surveying data. Logistic regression model was used to evaluate the relationship between the duration of full breastfeeding, the time of complementary feeding and the risk of anemia in infants at 12 month old and 48-71 months of age. The relationship between these two factors and the hemoglobin concentration of infants was measured by a linear regression model. The main results of this study are as follows: (1) in the study of the relationship between the duration of total breastfeeding and anemia, a total of 25393 infants were included in the analysis of 12 month old, and 32658 children were included in the analysis of 48-71 months old. Compared with less than 3 months of full breastfeeding found, more than 6 months of full breastfeeding and infant anemia in December at the age of increased risk was significantly related to OR correction value of 1.15 (95%CI:1.02,1.29), at 48-71 months of age was significantly related to the edge correction value of OR was 1.13 (95%CI:0.99,1.29). However, whether the December age babies or children 48-71 months of age, more than 6 months of full breastfeeding and lower hemoglobin concentrations were significantly correlated. (2) in the study of the relationship between the time and type of supplementary food and the relationship between anemia and anemia, a total of 18446 children of 48-71 months of age were included in the analysis. It was found that the supplement of complementary foods at 3-6 months old was significantly associated with the risk of anemia. The corrected OR value was 1.14 (95%CI:1.01-1.28), which was also significantly correlated with the decrease of hemoglobin concentration. The corrected mean difference was -0.84g/L (95%CI:-1.33, -0.35). In the different types of food, the correlation is mainly in the vegetable food such as bread / roast steamed bread / noodle, rotten surface / biscuit, tofu and so on. To sum up, the whole milk feeding time is too long (over 6 months) or complementary early (add 3-6 months) were associated with increased risk of infant anemia and hemoglobin concentration decreased. This is in accordance with WHO's present recommendation for full breastfeeding in the first 6 months of the baby and the addition of supplementary food at 6 month old. Therefore, after 6 months of full breastfeeding, parents should pay attention to giving their children a sufficient source of iron to prevent the occurrence of anemia.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R725.5

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