治疗高脂血症方剂的配伍应用探讨

发布时间：2018-01-04 04:35

本文关键词：治疗高脂血症方剂的配伍应用探讨　出处：《南京中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的在全面总结古今医家对于高脂血症认识的基础上,通过系统整理和研究现代文献中治疗高脂血症的有效方剂,探讨临床治疗高脂血症方剂的核心药物及其常用配伍,及合理用药思路以期揭示其遣药制方规律,为高脂血症的临床治疗提供理论依据,也为开发新的治疗高脂血症的中药复方提供有益的参考。方法本研究按步骤进行文献收集、资料筛选、数据库建立、数据分析相关工作。对中国知网2006年1月到2015年12月之间关于中医药治疗高脂血症的相关文献进行检索,收集筛选符合标准的文献,共纳入研究型文献193篇,对证候类型、治法和方剂的配伍用药进行统计分析。结果高脂血症的证型居前5位的分别为痰瘀互结证(93/28.70%)、痰浊阻遏证(45/13.89%)、肝肾阴虚证(33/10.19%)、气滞血瘀证(27/8.33%)、脾肾阳虚证(19/5.86%)。居前5位的高脂血症治则分别为祛痰化瘀(93/28.70%)、燥湿化痰(45/13.89%)、滋补肝肾(33/10.19%)、行气活血(27/8.33%)、温补脾肾(19/5.86%)。由此得到治疗高脂血症的中药处方324个,通过分析中药的方剂成分,参与治疗高脂血症的中药共有177种,其中用药频数在100次以上者9味,分别为山楂(277/7.66%)、丹参(238/6.58%)、泽泻(208/5.75%)、茯苓(165/4.56%)、何首乌(162/4.48%)、决明子(151/4.18%)、半夏(147/4.07%)、白术(137/3.79%)、黄芪(106/2.93%)。2味药之配伍药对(50频数)使用频数居前10位的高脂血症2味药药组为山楂、丹参、泽泻、何首乌、决明子、茯苓、白术。3味药之配伍药对(50频数)使用频数居前10位的高脂血症3味药药组为山楂、泽泻、丹参、何首乌、决明子、茯苓、白术。结论中医药治疗高脂血症具有良好的疗效,与联合西药治疗为增强降脂作用,并且无西药治疗带来的不良反应,具有停药后不反弹的优点。通过现代药物化学对处方中的中药材成分的分析,这些中药材含有能够降低血脂的天然药物成分,这些中药材相互协作,有利于降低血脂。中医药治疗高脂血症有待进一步研究,指导中药方剂的开发和中成药的生产,更大的发挥中医药在治疗高脂血症方面的优势,促进中医药事业的健康发展。
[Abstract]:Objective on the basis of summing up the understanding of hyperlipidemia among ancient and modern doctors, the effective prescription for treating hyperlipidemia in modern literature was systematically studied. To explore the clinical treatment of hyperlipidemia prescription of the core drugs and their common compatibility, and rational thinking of drug use in order to reveal the law of prescription, for the clinical treatment of hyperlipidemia to provide a theoretical basis. It also provides a useful reference for the development of a new Chinese medicine compound for hyperlipidemia. Methods this study was conducted according to the steps of literature collection, data screening, database establishment. Data analysis related work. From January 2006 to December 2015, the relevant literature on Chinese medicine treatment of hyperlipidemia was searched, and the literature that met the criteria was collected and screened. A total of 193 research papers were included. The types of syndromes, the combination of treatment methods and prescriptions were statistically analyzed. Results the top five syndromes of hyperlipidemia were phlegm and blood stasis syndromes (93 / 28.70). The syndrome of stagnation of phlegm and turbidity was 45 / 13.89, the liver and kidney yin deficiency was 33 / 10.19, and the syndrome of qi stagnation and blood stasis was 27 / 8.33). The top 5 hyperlipidemia patients were 93 / 28.70m of removing phlegm and removing blood stasis, and 45 / 13.89 of dampness of phlegm). Invigorating the liver and kidney at 33 / 10.19%, activating qi and activating blood by 27 / 8.33, warming up the spleen and kidney, warming up the spleen and kidney, 19 / 5.86. Thus, 324 Chinese medicine prescriptions for the treatment of hyperlipidemia were obtained. By analyzing the ingredients of traditional Chinese medicine, 177 kinds of Chinese medicines were involved in the treatment of hyperlipidemia, among which 9 kinds of drugs were used more than 100 times, which were Hawthorn (277 / 7.66). Salvia miltiorrhiza 238 / 6.58%, Rhizoma Alismatis 20.8 / 5.75m, Poria cocos 165 / 4.56a, Rhizoma Polygoni multiflorum 162R / 4.48. The seed of Cassia is 151 / 4.18, and it's 14.7 / 4.07 and 13.7 / 3.79. Astragalus membranaceus 106R / 2.93B. 2 prescription drugs for 50 frequency) the top 10 drugs with hyperlipidemia were Hawthorn, Salvia miltiorrhiza, Radix Alismatis, Radix Polygoni multiflorum, Cassia seed, Poria cocos, and the other two kinds of drugs were Hawthorn, Salvia miltiorrhiza, Radix Polygoni multiflorum. The combination of Atractylodes macrocephala (Rhizoma Atractylodes Rhizoma Atractylodes) and its compatibility with 50 frequency) the top 10 drugs with hyperlipidemia were Hawthorn, alisma, Salvia miltiorrhiza, Radix Polygoni multiflorum, Cassia seed, Poria cocos. Conclusion traditional Chinese medicine has a good curative effect on hyperlipidemia, combined with western medicine to enhance the effect of lipid-lowering, and there is no adverse reaction caused by western medicine treatment. It has the advantage of not bouncing back after withdrawal. By analyzing the ingredients of Chinese medicinal materials in prescriptions by modern pharmacochemistry, these Chinese medicines contain natural ingredients that can reduce blood lipid, and these Chinese medicines cooperate with each other. In order to reduce blood lipids. Chinese medicine treatment of hyperlipidemia needs to be further studied to guide the development of traditional Chinese medicine prescription and the production of proprietary Chinese medicine to play a greater advantage in the treatment of hyperlipidemia. To promote the healthy development of Chinese medicine.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R289.5

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