胃黏膜不同萎缩范围的血清学分析

发布时间：2018-01-06 14:14

本文关键词：胃黏膜不同萎缩范围的血清学分析　出处：《广西医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:慢性萎缩性胃炎是胃癌的主要癌前疾病,血清胃蛋白酶原(PG)和胃泌素-17(G-17)是胃体和胃窦黏膜萎缩的血清学标志物。本研究旨在分析广西地区慢性萎缩性胃炎中不同萎缩范围的血清PG和G-17水平的变化,探讨血清学检测对筛查慢性萎缩性胃炎的临床意义。方法:收集2015年12月至2016年8月在广西壮族自治区人民医院行上消化道内镜检查符合入组标准者共125例,根据病理结果分为对照组(包括正常和非萎缩性胃炎)和萎缩性胃炎组。根据木村-竹本提出的慢性萎缩性胃炎的萎缩分型系统,将萎缩性胃炎组细分为A组(C1)、B组(C2+C3)、C组(O1+O2+O3)和D组(O4)四个不同萎缩范围的亚组。同时检测血清PGI、PGII、PGI/PGII(PGR)、G-17水平,分析比较各组血清学指标的水平变化。结果:1.对照组共56例,萎缩性胃炎组共69例(其中A组21例,B组31例,C组12例,D组5例)。2.血清PG水平:萎缩性胃炎组的PGI和PGR水平低于对照组(P0.05),且胃窦伴胃体萎缩(B+C+D组)的PGI和PGR水平明显低于单纯胃窦萎缩(A组)和对照组(P0.05)。萎缩性胃炎组中,由A到D组,PGI和PGR水平呈逐渐下降趋势,其中PGR的下降趋势具有显著性(P0.05)。PGII水平在萎缩性胃炎组显著高于对照组(P0.05),在萎缩性胃炎组各亚组间无显著差异(P0.05)。3.血清G-17水平:萎缩性胃炎组的G-17水平明显低于对照组(P0.05)。萎缩性胃炎组中,G-17水平在各组间无显著差异(P0.05)。结论:1.血清PGI和PGR水平(尤其是PGR)随着胃黏膜萎缩范围的变广,呈一定的下降趋势。2.联合检测血清PG和G-17对预测胃黏膜萎缩部位及范围具有一定参考价值。3.动态检测血清PGI和PGR水平对监测胃黏膜萎缩病变的发展可能具有一定的临床价值。
[Abstract]:Objective: chronic atrophic gastritis is the main precancerous disease of gastric cancer. Serum pepsinogen) and gastrin-17 G-17). This study was designed to analyze the changes of serum PG and G-17 levels in different atrophy areas of chronic atrophic gastritis in Guangxi. To explore the clinical significance of serological examination in screening chronic atrophic gastritis. From December 2015 to August 2016, a total of 125 cases of upper gastrointestinal endoscopy were collected from Guangxi Zhuang Autonomous region people's Hospital. According to the pathological results were divided into control group (including normal and non-atrophic gastritis) and atrophic gastritis group. The patients with atrophic gastritis were subdivided into four subgroups with different atrophic ranges: group A, C, C, C, C, C, C, C, C, C, C, O 2, O 2, O 3, and D, and the serum PGI levels were detected at the same time. The serum levels of PGI / PGI / PGI / PGRN G-17 were analyzed and compared in each group. Results: 1.The control group consisted of 56 cases. There were 69 cases of atrophic gastritis (including 21 cases in group A, 31 cases in group B and 12 cases in group C). Serum PG level: the levels of PGI and PGR in the atrophic gastritis group were lower than those in the control group (P 0.05). The levels of PGI and PGR in the antrum with atrophy of gastric body (B C D group) were significantly lower than those in the simple antrum atrophy group (A group) and the control group (P 0.05). In the atrophic gastritis group, the levels of PGI and PGR were significantly lower than those in the group A to D. The levels of PGI and PGR decreased gradually, and the level of PGR in the atrophic gastritis group was significantly higher than that in the control group (P 0.05). There was no significant difference among the subgroups in atrophic gastritis group (P 0.05). 3. Serum G-17 level: the G-17 level in atrophic gastritis group was significantly lower than that in control group (P0.05). In atrophic gastritis. There was no significant difference in G-17 levels among the groups (P 0.05). Conclusion: 1. Serum PGI and PGR levels (especially PGRs) increased with gastric mucosal atrophy. The combined detection of serum PG and G-17 has certain reference value in predicting the location and range of gastric mucosal atrophy. 3. Dynamic detection of serum levels of PGI and PGR is useful for monitoring gastric mucosal wilting. The development of contractive lesions may have some clinical value.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R573.32

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