痹宁胶囊对湿热蕴结型急性痛风性关节炎的临床疗效观察

发布时间：2018-01-07 07:20

本文关键词：痹宁胶囊对湿热蕴结型急性痛风性关节炎的临床疗效观察　出处：《黑龙江中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:观察痹宁胶囊治疗急性痛风性关节炎(湿热蕴结型)的有效性以及对IL-1β及IL-18的影响。方法:本研究从黑龙江中医药大学附属第一医院风湿科门诊共筛选出符合诊断标准的患者40例,按照随机原则分为2组,每组20例。其中对照组予秋水仙碱口服;治疗组在对照组基础上予痹宁胶囊口服。两组在治疗过程中均进行基础治疗,疗程为10d。10d后观察两组患者中医证侯总疗效和积分、VAS评分、实验室指标(UA、ESR、CRP)及细胞因子(IL-1β、IL-18)水平的变化。详细记录各项指标后进行统计学分析。结果:1.中医证侯总疗效:治疗组中医证侯总有效率为90.0%,对照组中医证候总有效率为70.0%,两组相比差异有统计学意义(P0.05),治疗组优于对照组。2.中医证侯积分:治疗组与对照组均可改善患者的中医证候积分,两组对比差异有统计学意义(P0.05),治疗组优于对照组。3.VAS评分:治疗组与对照组均可改善患者的VAS评分,两组对比差异有统计学意义(P0.05),治疗组优于对照组。4.相关实验室指标:治疗组在降低痛风性关节炎患者血尿酸、血沉、C-反应蛋白方面均优于对照组,差异具有统计学意义(P0.05)。5.细胞因子:治疗组在降低痛风性关节炎患者IL-1β及IL-18表达方面均优于对照组,差异具有统计学意义(P0.05)。结论:1.痹宁胶囊能够有效减轻急性痛风性关节炎患者(湿热蕴结型)的疼痛及相关临床症状。2.痹宁胶囊能够降低急性痛风性关节炎患者(湿热蕴结型)血尿酸水平、血沉水平及C-反应蛋白水平,说明痹宁胶囊可以改善急性痛风性关节炎患者实验室指标。3.痹宁胶囊能够降低急性痛风性关节炎患者(湿热蕴结型)血清IL-1β和IL-18的水平,说明痹宁胶囊治疗急性痛风性关节炎的机制与抑制细胞因子的表达密切相关。
[Abstract]:Objective: To observe the effect of Bi Ning Capsule in the treatment of acute gouty arthritis (shireyunjiexing) the effectiveness and impact of IL-1 beta and IL-18. Methods: This study from the First Affiliated Hospital of Heilongjiang University Of Chinese Medicine, Department of rheumatism clinic were screened 40 patients met the diagnostic criteria, were randomly divided into 2 groups, 20 cases in each group. The control group was treated with oral colchicine; the treatment group in the control group based on the given Bi capsule. The two groups in the course of treatment was given the basic treatment, treatment for 10d.10d after the two groups were observed in patients with TCM syndrome total curative effect and the integral, VAS score, laboratory indexes (UA, ESR, CRP) and cytokines (IL-1 beta IL-18), changes in the level of statistical analysis. Detailed records of each index. Results: 1. TCM syndrome total curative effect: treatment group TCM syndrome total effective rate was 90%, the control group of TCM syndrome total effective rate was 70%. The difference between the two groups have Statistical significance (P0.05), the control group.2. TCM syndrome score: the treatment group and the treatment group than the control group could improve the TCM syndrome scores, there were statistically significant differences between the two groups (P0.05), the control group is better than the.3.VAS score of treatment group: treatment group and control group all can improve the patient's VAS score, there are statistically significant differences between the two groups (P0.05), the control group of.4. related laboratory index of treatment group than the treatment group in the patients with gouty arthritis reduce blood uric acid, erythrocyte sedimentation rate, C- reactive protein were better than the control group, the difference has statistical significance (P0.05):.5. cytokines in the treatment group decreased IL-1 in patients with gout in beta and IL-18 expression were better than the control group, the difference was statistically significant (P0.05). Conclusion: 1. bining capsule can effectively reduce the patients with acute gouty arthritis (shireyunjiexing) pain and related clinical symptoms of.2. syndrome Ning capsule can reduce the patients with acute gouty arthritis (shireyunjiexing) level of serum uric acid levels, erythrocyte sedimentation rate and C-reactive protein C-, that Bi Ning capsule can improve the acute gout arthritis laboratory indexes in patients with.3. Bi Ning capsule can reduce the patients with acute gouty arthritis (shireyunjiexing) serum IL-1 beta and IL-18 the level of description mechanism of bining capsule in the treatment of acute gouty arthritis is closely related with inhibiting the expression of cytokines.

【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R589.7

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