三参四黄降糖胶囊治疗早期糖尿病肾病临床疗效观察

发布时间：2018-01-11 04:09

本文关键词：三参四黄降糖胶囊治疗早期糖尿病肾病临床疗效观察　出处：《湖北民族学院》2017年硕士论文　论文类型：学位论文

【摘要】：目的:本研究旨在观察三参四黄降糖胶囊对早期糖尿病肾病(气阴两虚夹瘀证)的临床疗效及对血清肿瘤坏死因子(TNF-α)的干预。方法:将选取符合纳入标准的患者60例,随机分为两组(对照组、治疗组),每组30例。两组均进行常规基础治疗及糖尿病宣教,对照组加用厄贝沙坦治疗,治疗组加用三参四黄降糖胶囊治疗。总疗程为12周,疗程结束后检测两组患者的尿微量白蛋白排泄率(UAER)、血清TNF-α等生化指标,分析治疗前后临床疗效及中医证候积分变化,并结合安全性指标,对两组进行综合比较。结果:1.治疗12周后观察,两组总有效率比较:治疗组为82.1%,对照组总有效率25.0%,差异显著,有统计学意义(p0.05),说明三参四黄降糖胶囊治疗早期糖尿病肾病作用突出,区别于传统治疗具有明显优势。2.治疗12周后观察,在中医证候总积分及症状积分方面:两组间比较,治疗组较对照组下降明显(p0.05);治疗组组内比较,较治疗前显著下降(p0.05)在中医有效率方面:治疗组92.0%,对照组17.9%,两组比较差异显著(p0.05),有统计学意义。表明,三参四黄降糖胶囊在改善中医证候、症状方面具有独特疗效。3.治疗12周后观察,在降低UAER方面:治疗组较治疗前明显降低(p0.05);治疗组较对照组明显下降(p0.05),差异显著,具有统计学意义。证实,三参四黄降糖胶囊可显著降低早期糖尿病肾病UAER水平。4.治疗12周后观察,在降低血清TNF-α方面:治疗组较治疗前明显降低(p0.05);对照组较治疗前轻微升高;治疗组较对照组明显下降(p0.05)差异显著,具有统计学意义。说明三参四黄降糖胶囊可显著降低早期糖尿病肾病患者血清TNF-α水平。结论:1.三参四黄降糖胶囊可降低早期糖尿病肾病患者UAER水平,说明可降低肾小球损伤及蛋白尿的产生。2.三参四黄降糖胶囊可明显改善早期糖尿病肾病患者中医临床症状及体征,降低证候积分。3.三参四黄降糖胶囊可通过降低患者血清TNF-α的水平,延缓早期糖尿病肾病病情进展。4.三参四黄降糖胶囊安全性高,药物及使用剂量可靠。
[Abstract]:Objective: This study aimed to investigate the three ginseng four yellow Jiangtang Capsule on early diabetic nephropathy (Qi Yin deficiency with blood stasis syndrome) clinical efficacy and factors on serum tumor necrosis (TNF- alpha) intervention. Methods: 60 patients were enrolled according to inclusion criteria, were randomly divided into two groups (control group, treatment group), 30 cases in each group. Two groups were received routine treatment and diabetes education, the control group treated with irbesartan, the treatment group was treated with three parameters of four yellow Jiangtang Capsule treatment. The total treatment duration was 12 weeks after the end of treatment, detection of urinary albumin excretion rate in two groups (UAER), serum TNF- biochemical indicator. Analysis of the changes of the integral clinical curative effect and TCM syndrome before and after treatment, and combined with the safety indexes of the two groups were compared. Results: the observation of 1. after 12 weeks of treatment, the total efficiency of two groups: the treatment group was 82.1%, control group total effective rate was 25%, there was significant difference. (P0.05), meaning that three and four yellow Jiangtang Capsule in treating early diabetic nephropathy have outstanding effect, different from the traditional treatment has the obvious advantages of.2. after 12 weeks of treatment, the TCM syndrome total score and symptom score: comparison between the two groups, the treatment group significantly decreased compared with the control group (P0.05); treatment group in comparison, significantly lower than before treatment (P0.05) efficiency in traditional Chinese medicine: the treatment group 92%, control group 17.9%, there was significant difference between two groups (P0.05), there was statistical significance. Three parameters showed that four yellow Jiangtang Capsule in improving TCM syndrome, the symptoms have unique curative effect observation of.3. after 12 weeks of treatment and the reduction of UAER in treatment group were significantly lower than those before treatment (P0.05); the treatment group decreased significantly compared with the control group (P0.05), significant difference was statistically significant. Three confirmed, four yellow ginseng Jiangtang Capsule can significantly reduce the level of UAER.4. in early diabetic nephropathy after 12 weeks of treatment Observation on serum alpha TNF- treatment group was significantly lower than before treatment (P0.05); the control group is slightly higher than before treatment; the treatment group decreased significantly compared with the control group (P0.05) had significant difference, with statistical significance. Three refs four yellow Jiangtang Capsule could significantly decrease the serum TNF- in patients with early diabetic nephropathy alpha level. Conclusion: 1. three ginseng four yellow Jiangtang Capsule can reduce the level of UAER in patients with early diabetic nephropathy, that can reduce glomerular injury and proteinuria in.2. three ginseng four yellow Jiangtang Capsule can obviously improve the traditional Chinese medicine for early diabetic nephropathy patients clinical symptoms and signs, reduce the symptom score of.3. three. Four yellow Jiangtang Capsule can reduce patients serum TNF- level, delay the disease progression of diabetic nephropathy early.4. three ginseng four yellow Jiangtang Capsule with high safety, drugs and dosage.

【学位授予单位】：湖北民族学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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