理冲生髓饮对卵巢癌术后化疗患者减毒作用的疗效分析

发布时间：2018-01-16 12:03

本文关键词：理冲生髓饮对卵巢癌术后化疗患者减毒作用的疗效分析　出处：《黑龙江中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:评价理冲生髓饮对卵巢癌术后TP方案化疗患者的近期临床疗效及其减毒作用。方法:卵巢癌术后拟化疗患者80例,随机分为中药组(LCSSY+TP方案化疗)和对照组(TP方案化疗),每组各40例。治疗三疗程后观察患者肿瘤标志物CA125水平的变化、中医证候疗效评分、体力评分、生活质量评分及毒副反应情况。结果:1.治疗后两组患者的CA125水平相比较,中药组患者CA125下降幅度大于对照组,差异有统计学意义(P0.05)。2.治疗后两组患者的中医证候疗效积分、卡氏评分及生活质量评分相比较,中药组改善情况均优于对照组,差异有统计学意义(P0.05)。3.治疗后两组患者骨髓抑制情况及恶心呕吐情况相比较,中药组骨髓抑制及消化道不良反应较轻,差异均有统计学意义(P0.05);治疗后两组患者谷丙转氨酶、血肌酐、血尿素氮及血尿分度情况相比,差异均有统计学意义(P0.05),蛋白尿分度情况相比,差异无统计学意义(P0.05),表明相比对照组,中药组肝肾功能损伤较少。在治疗期间两组患者针对骨髓抑制及肝肾功损伤的对症干预情况相比有显著差异(P0.01)。结论:1.理冲生髓饮有助于降低卵巢癌患者肿瘤标志物CA125水平。2.理冲生髓饮有助于改善卵巢癌术后化疗患者的中医证候及体力状况并提高其生存质量。3.理冲生髓饮可缓解卵巢癌术后化疗患者的骨髓抑制及消化道不良反应。4.理冲生髓饮可在一定程度上减轻卵巢癌术后化疗患者的肝肾功能损伤。
[Abstract]:Objective: to evaluate the short-term clinical effect and attenuated effect of Lichong Shengmai decoction in patients with ovarian cancer treated with TP regimen. Methods: 80 patients with ovarian cancer were treated with chemotherapy. The patients were randomly divided into two groups: the traditional Chinese medicine group (LCSSY TP regimen) and the control group (40 cases in each group). The changes of tumor marker CA125 were observed after three courses of treatment. TCM syndromes efficacy score, physical strength score, quality of life score and toxic side effects. Results: 1. Comparison of CA125 levels between the two groups after treatment. The decrease of CA125 in the Chinese medicine group was greater than that in the control group, and the difference was statistically significant (P 0.05. 2). After treatment, the TCM syndromes curative effect score, Carson's score and quality of life score of the two groups were compared. The improvement of the traditional Chinese medicine group was better than that of the control group, the difference was statistically significant (P 0.05). 3. After treatment, the two groups of patients with bone marrow suppression and nausea and vomiting were compared. The bone marrow inhibition and digestive tract adverse reactions in the Chinese medicine group were mild, and the difference was statistically significant (P 0.05). After treatment, the two groups of patients with glutamate-alanine aminotransferase, serum creatinine, blood urea nitrogen and blood urine grading, the differences were statistically significant (P 0.05), compared with the proteinuria grading. The difference was not statistically significant (P 0.05), indicating that compared with the control group. There was significant difference between the two groups in the intervention of bone marrow suppression and liver and kidney function injury during the treatment period (P 0.01). ... conclusion:. 1. Lichongshengmei decoction can reduce the level of tumor marker CA125 in patients with ovarian cancer. Lichongshengmai decoction can improve the TCM syndromes and physical strength of patients with ovarian cancer after chemotherapy and improve their quality of life. 3. Lichongshengmei decoction can relieve bone marrow depression and digestive tract adverse reaction of patients with ovarian cancer after chemotherapy .4.Lichong Shengmai decoction can alleviate liver and kidney function injury in patients with ovarian cancer after chemotherapy to a certain extent.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.31

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