低功率激光治疗轻型复发性阿弗他溃疡的临床实验研究

发布时间：2018-01-19 23:50

本文关键词： 半导体激光 Nd:YAG激光轻型复发性阿弗他溃疡临床疗效　出处：《安徽医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的本实验通过临床病例,实验一对比半导体激光与复方氯己定含漱液治疗轻型复发性阿弗他溃疡(minor recurrent aphthous ulcer,Mi RAU)的疗效,并探讨同一波长不同功率激光与其疗效的关系,以选出治疗Mi RAU的有效最适剂量,为激光治疗Mi RAU提供依据;实验二比较波长1064 nm Nd:YAG激光和波长810 nm半导体激光治疗Mi RAU的疗效,以选出治疗Mi RAU的有效最优激光。方法实验一:2015年3月~2016年11月,选择临床确诊的90例Mi RAU患者,随机分成3组,每组30例。实验组分别采用波长810 nm,频率300mw和波长810nm,频率500mw半导体激光局部照射Mi RAU,对照组采用复方氯己定含漱液治疗Mi RAU,比较3组治疗前后患者的疼痛缓解率、溃疡愈合时间、溃疡面积及疗效有效率。实验二:2015年3月~2016年11月,选择口腔黏膜上有2个散在Mi RAU的患者50例,共计100个溃疡。每个溃疡随机分为波长1064 nm Nd:YAG激光治疗组和波长810nm半导体激光治疗组,进行连续3d局部激光治疗。分别在第1、2、3天治疗后即刻和第4天随访时记录患者的疼痛指数,比较溃疡的愈合状况,记录最终愈合时间。结果实验一:激光治疗组和对照组治疗前后比较,激光治疗组的疼痛缓解率高于对照组,溃疡愈合时间和面积均少于对照组,比较差异具有统计学意义(P0.05);波长810nm,频率300mw激光治疗组缓解疼痛效果优于波长810nm,频率500mw组和对照组。激光治疗组总有效率优于对照组(P0.05),波长810nm,频率300mw和波长810nm,频率500mw组差异无统计学意义(P0.05)。实验二:波长1064 nm Nd:YAG激光治疗组和波长810nm半导体激光治疗组在治疗第1、2及第4天随访时疼痛指数差异无统计学意义(P0.05),第3天时两组之间的差异具有统计学意义(P0.05);2组愈合时间差异无统计学意义(P0.05)。结论实验一:半导体激光能有效缓解Mi RAU所产生的疼痛感并且作用持久,能显著缩短溃疡愈合的时间。波长为810 nm条件下,功率300 mw,功率密度为1.53 W/CM2的半导体激光的缓解疼痛效果最优。实验二:Nd:YAG激光和半导体激光低能量照射治疗Mi RAU疗效相同,均充分利用了激光的生物刺激作用、热效应,能减轻患者疼痛、促进溃疡愈合,显著提高疗效。
[Abstract]:Objective this experiment passes the clinical case. Experiment 1 compared semiconductor laser with compound chlorhexidine gargle in the treatment of minor recurrent aphthous ulcer of mild recurrent aphthous ulcer. The effect of Mi RAU) and the relationship between the different power laser of the same wavelength and its curative effect were discussed in order to select the optimal dosage for the treatment of Mi RAU and to provide the basis for laser treatment of Mi RAU. The second experiment was to compare the efficacy of 1064nm Nd:YAG laser and 810nm semiconductor laser in the treatment of Mi RAU. Methods: from March 2015 to November 2016, 90 patients with Mi RAU were randomly divided into 3 groups. There were 30 cases in each group. The experimental group received local irradiation of Mi RAU with wavelength 810nm, frequency 300MW and wavelength 810nm, frequency 500MW semiconductor laser. The control group was treated with compound chlorhexidine gargle. The pain relief rate and ulcer healing time were compared before and after treatment. The area of ulcer and the effective rate. Experiment 2: from March 2015 to November 2016, 50 patients with Mi RAU were selected from oral mucosa. A total of 100 ulcers were randomly divided into two groups: wavelength 1064nm Nd:YAG laser treatment group and wavelength 810nm semiconductor laser treatment group. The pain index of the patients was recorded immediately after 3 days of treatment and 4 days after the treatment, and the healing status of the ulcer was compared. Results: compared with the control group, the pain relief rate of laser treatment group was higher than that of control group, and the healing time and area of ulcer in laser treatment group were lower than that in control group. The difference was statistically significant (P 0.05). The pain relief effect of the 300MW laser treatment group was better than that of the wavelength 810nm. The total effective rate in the laser treatment group was better than that in the control group (P 0.05), the wavelength was 810 nm, the frequency was 300 MW and the wavelength was 810 nm. There was no significant difference in frequency 500MW group (P0.05). Experiment 2: wavelength 1064nm Nd:YAG laser treatment group and wavelength 810nm semiconductor laser treatment group in the first treatment. There was no significant difference in pain index between the two groups at 2 and 4 days follow-up, but the difference between the two groups on the third day was statistically significant. There was no significant difference in healing time between the two groups (P 0.05). Conclusion experiment 1: semiconductor laser can effectively relieve the pain caused by Mi RAU and the effect is lasting. The healing time of ulcers was significantly shortened, and the power was 300 MW at 810 nm. The pain relief effect of semiconductor laser with power density of 1.53 W / CM2 was the best. Experiment 2: ND: YAG laser and semiconductor laser low energy irradiation had the same effect on Mi RAU. All of them make full use of the biological stimulation and heat effect of laser, which can relieve the pain of the patients, promote the healing of ulcers, and improve the curative effect significantly.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R781.5

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