止咳平喘汤对咳嗽变异性哮喘（风盛挛急证）的临床观察及对血清中EOS、IL-10的影响

发布时间：2018-02-21 03:25

  本文关键词： 咳嗽变异性哮喘 止咳平喘汤 风盛挛急证 EOS、IL-10　出处：《黑龙江中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:观察止咳平喘汤对咳嗽变异性哮喘(风盛挛急证)的临床疗效及对血清中EOS、IL-10的影响。方法:将60例黑龙江中医药大学附属第一医院呼吸科门诊,因咳嗽变异性哮喘(风盛挛急证)来就诊的患者作为研究对象,采用随机对照法分为治疗组、对照组。治疗组30例给予止咳平喘汤剂;对照组30例给予孟鲁司特钠;疗程均为2周。观察两组患者治疗前后咳嗽评分、中医证候积分及有效率、血清中EOS、IL-10的变化情况。结果:1.止咳平喘汤可以有效改善咳嗽评分及中医证候积分,与对照组比较有统计学意义(P0.05)。2.止咳平喘汤临床疗效显著,其总有效率96.7%,与对照组比较有统计学意义(P0.05)。3.两组患者治疗后EOS百分比下降(P0.05),IL-10含量上升(P0.05),组间比较差异无统计学意义(P0.05)。结论:1.止咳平喘汤对咳嗽变异性哮喘(风盛挛急证)1临床疗效显著,可改善患者的临床症状。2.止咳平喘汤可有效降低血清EOS水平、提高IL-10含量,与对照组比较临床疗效相当,具有良好安全性,值得在临床上推广运用。
[Abstract]:Objective: to observe the clinical effect of Zhike Pingchuan decoction on cough variant asthma (Fengsheng clonic acute syndrome) and its effect on serum EOS-IL-10. Methods: 60 cases of respiratory clinic of the first affiliated Hospital of Heilongjiang University of traditional Chinese Medicine were selected. Patients with cough variant asthma (Fengsheng clonic acute syndrome) were randomly divided into two groups: treatment group (n = 30), control group (n = 30), control group (n = 30), control group (n = 30), control group (n = 30) were treated with montelukast sodium, and the control group (n = 30) were given montelukast sodium. The course of treatment was 2 weeks. The cough score, TCM syndromes score and effective rate before and after treatment, and the changes of EOS-IL-10 in serum were observed. Results: 1. Zhike Pingchuan decoction could effectively improve cough score and TCM syndrome score. Compared with the control group, there was significant difference in the clinical effect of Zhike Pingchuan decoction. Compared with the control group, the total effective rate was 96.7. there was statistical significance between the two groups. After treatment, the percentage of EOS in the two groups decreased and the content of IL-10 increased. There was no significant difference between the two groups. Conclusion: 1. Zhike Pingchuan decoction is effective in treating cough variant asthma. The clinical effect of acute clonus syndromes was significant. Zhike Pingchuan decoction can effectively reduce the level of serum EOS and increase the content of IL-10. Compared with the control group, it has good clinical efficacy and good safety. It is worth popularizing in clinic.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R256.12

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