血瘀体质多囊卵巢综合征患者临床及生化特征分析

发布时间：2018-03-04 10:19

本文选题：多囊卵巢综合征　切入点：血瘀体质　出处：《黑龙江中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:通过对230例多囊卵巢综合征患者的中医体质、外在体征、临床及生化特征进行采集与分析,探讨血瘀体质PCOS患者的临床特征与糖、脂代谢等生化指标的关系。通过对血瘀体质和非血瘀体质PCOS的外在体征、临床及生化特征等进行比较,更好的明确血瘀体质多囊卵巢综合征的诊断,发挥中医药的优势预防血瘀体质PCOS的发生并提高其治疗效果。方法:选择于2015年1月至2016年12月就诊于黑龙江中医药大学附一院妇科门诊的符合纳入标准的PCOS患者。由受过培训的专业人员进行多毛、痤疮、黑棘皮、溢脂评分,并询问月经情况,进行实验室生化检查。并由患者独立填写《中医体质量表》,按《中医体质分类与判定》进行体质类型判定,分为血瘀体质和非血瘀体质。对两组资料数据进行整理,通过卡方检验、t-检验等统计学方法的分析得出相关结论。结果:1两组间年龄、初潮年龄、BMI、腰围、臀围、腰臀比、收缩压、舒张压差异无统计学意义(P0.05)。2 两组间 LH、FSH、LH/FSH、SHBG、AND、FPG、FINS、HOMA-IR、TG、TC、LDL、APOB、脂蛋白a水平,差异无统计学意义(P0.05)。而血瘀体质组患者T、DHEAS水平低于非血瘀体质组,差异有统计学意义(P0.05)。血瘀体质组患者的HDL、APO-A水平高于非血瘀体质组,差异有统计学意义(P0.05)。3两组间多毛、痤疮评分差异无统计学意义(P0.05)。血瘀体质组患者的黑棘皮发生率高于倾向血瘀体质组和非血瘀体质组差异有统计学意义(P0.05)。两组间溢脂评分有显著差异性(P0.01)。结论:1 PCOS患者中医体质分布中以血瘀质、气虚质和痰湿质最为常见,血瘀质PCOS患者所占比例最大。2血瘀体质PCOS患者较非血瘀体质患者更容易出现的T、DHEAS、HDL、A-POA 的异常。3血瘀体质PCOS患者和非血瘀体质患者的黑棘皮发生率和溢脂评分有显著差异性。4在临床中可以根据PCOS的中医证型、体质类型,通过辩证论治、辩体调质的思想指导PCOS的治疗。此外,调整偏颇体质对于PCOS的预防和改善PCOS患者临床症状具有重要意义。
[Abstract]:Objective: to investigate the clinical features and sugar of PCOS patients with blood stasis by collecting and analyzing the physique, physical signs, clinical and biochemical characteristics of traditional Chinese medicine (TCM) in 230 patients with polycystic ovary syndrome (PCOS). The relationship between lipid metabolism and other biochemical indexes. By comparing the external signs, clinical and biochemical characteristics of blood stasis constitution and non-blood stasis constitution PCOS, the diagnosis of blood stasis constitution polycystic ovary syndrome was better defined. To give full play to the advantages of Chinese medicine to prevent the occurrence of blood stasis constitution PCOS and improve its therapeutic effect. Methods: select from January 2015 to December 2016 to visit the gynecological outpatient department of the first affiliated Hospital of Heilongjiang University of traditional Chinese Medicine to meet the inclusion criteria of PCOS patients. By trained professionals, Acne, black spinous skin, fat spill score, and enquire the menstruation condition, carry on the laboratory biochemical examination, and the patient independently fills in the traditional Chinese medicine constitution scale, according to the traditional Chinese medicine constitution classification and the judgment carries on the constitution type determination, It is divided into two groups: blood stasis constitution and non-blood stasis constitution. The data of the two groups are sorted out, and the relevant conclusions are drawn by statistical methods such as chi-square test and t- test. Results the age, menarche age, waist circumference, hip circumference, waist-hip ratio between the two groups were measured. There was no significant difference in systolic blood pressure (SBP) and diastolic blood pressure (DBP) between two groups (P < 0.05). The level of TDHEAS in the two groups was lower than that in the non-blood stasis constitution group, but the level of TDHEAS in the blood stasis constitution group was lower than that in the non-blood stasis constitution group. The difference was statistically significant (P 0.05). The level of HDL APO-A in the blood stasis constitution group was higher than that in the non-blood stasis constitution group, and the difference was statistically significant (P 0.05). There was no significant difference in acne score between the two groups (P 0.05). The incidence of acanthosis in the blood stasis constitution group was higher than that in the blood stasis constitution group and non-blood stasis constitution group (P 0.05). There was a significant difference in the fat spill score between the two groups (P 0.01). Conclusion: 1 PCOS. Blood stasis is used in the distribution of TCM constitution. Qi deficiency and phlegm dampness are the most common. The largest proportion of patients with PCOS with blood stasis. 2 the incidence of black ratchet skin and lipid spill score in patients with PCOS and non-blood stasis constitution were significantly lower than those in patients with non-blood stasis constitution. 3 abnormal blood stasis constitution PCOS patients and non-blood stasis constitution patients were more likely to appear in patients with PCOS than those with non-blood stasis constitution. 3. 3 blood stasis constitution PCOS patients and non-blood stasis constitution patients had significant differences in acanthosis rate and lipid spill score. Heterosexual. 4 in clinical practice, according to the TCM syndromes of PCOS, Physique type, through dialectical treatment, dialectical theory of body conditioning to guide the treatment of PCOS. In addition, adjustment of biased physique for the prevention of PCOS and improve the clinical symptoms of PCOS patients is of great significance.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R271.9

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