系统性红斑狼疮患者健康相关生活质量及常见影响因素研究

发布时间：2018-03-05 00:27

本文选题：系统性红斑狼疮　切入点：SF-36生活质量表　出处：《广西医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的评价系统性红斑狼疮(SLE)患者健康相关生存质量(HRQOL),研究影响患者HRQOL的主要因素;分析SLEDAI、SLAM两种SLE活动度评估系统对患者HRQOL评定结果的影响。方法记录41例SLE患者性别、年龄、学历、职业、病程、激素用量、疾病活动度(SLEDAI、SLAM)等常见因素,用SF-36生活质量表评估SLE患者的HRQOL,用t检验、配对t检验、person相关因素等方法分析各相关因素及其与SF-36量表各维度评估结果的相关性。结果本研究中41例SLE患者的HRQOL与中国常模相比,在SF-36量表的生理功能(PF)、生理职能(RP)、躯体疼痛(BP)、总体健康(GH)、活力(VT)、社会功能(SF)、情感职能(RE)、精神健康(MH)8个维度均有明显下降(p0.01);SLE患者年龄组与PF项,SLEDAI、SLAM两种疾病活动度测评组与PF、RP、GH、VT、RE项有相关性(p0.01或p0.05)。结论SLE患者的HRQOL主要受年龄、病情活动度的影响;SLEDAI、SLAM评价SLE患者的HRQOL作用大致相当。
[Abstract]:Objective to evaluate the health-related quality of life (HQOL) in patients with systemic lupus erythematosus (SLE), to study the main factors affecting HRQOL, and to analyze the influence of SLEDAI SLAM two kinds of SLE activity evaluation systems on the results of HRQOL evaluation. Methods 41 patients with SLE were recorded by sex and age. Educational background, occupation, course of disease, hormone consumption, disease activity and SLEDAI SLAM) were used to evaluate HRQOLs of SLE patients with SF-36 quality of life table, and t test was used to evaluate HRQOLs of SLE patients. The correlation between the relevant factors and the evaluation results of SF-36 scale was analyzed by paired t test. Results the HRQOL of 41 patients with SLE in this study was compared with the Chinese norm. In the physiological function of SF-36, the physiological function of SF-36, the physical function of SF-36, the somatic pain, the general health of GHG, the activity of VT, the social function, the affective function, the mental health, the eight dimensions of SF-36 all showed a significant decrease in the age group of patients with SF-36 and the activity of SLEDAI SLAM in the PF item. The evaluation group was associated with VTT RE item in SLE patients (P 0.01 or p 0.05). Conclusion the patients with SLE are mainly affected by HRQOL. The effect of SLEDAI SLAM in evaluating HRQOL in patients with SLE was approximately the same as that of SLEDAI SLAM.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R593.241

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