加味桂精汤治疗肝肾阴虚型早泄的临床观察

发布时间：2018-03-05 05:26

本文选题：早泄　切入点：肝肾阴虚　出处：《福建中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:观察加味桂精汤在延长射精潜伏时间、改善症状、提高患者自信心及增进夫妻情感方面对肝肾阴虚型早泄的治疗作用。方法:1.选取福建中医药大学附属人民医院男科门诊30例符合肝肾阴虚型早泄纳入标准的患者,均签署知情同意书,年龄在22-55岁之间,平均年龄(36.53±7.98)岁,采用自身对照的方法进行临床试验设计。2.对纳入者给予加味桂精汤口服治疗,每日一剂,每剂分2次冲服,疗程共4周,根据患者自身情况,服药期间每周至少房事一次。3.根据病人复诊情况,观察四个时间点临床疗效,于治疗前,治疗后1周、2周、4周的射精潜伏时间(若一周内只有一次性生活记录当次时间,若有多次取均值)、早泄诊断量表、中医症状变化情况,并观查患者服药后反应。结果:1.患者射精潜伏时间(IELT)变化情况:治疗前患者IELT在91.03±10.44秒范围,其最大值为106.00秒,最小值71.89秒,治疗四周后在242.75±88.50秒范围,其最大值为410.84秒,最小值为76.45秒,其中5例患者IELT较治疗前无延长,其余25例均不同程度延长,最大值为307.04秒,治疗前后数值比较(P0.01)有明显差异,具有统计学意义,有效率83.33%;2.患者早泄诊断量表(PEDT)评分情况:治疗前患者PEDT评分在13.27± 1.44范围,其最大值为16分,最小值10分,治疗四周后在5.97±3.15范围,其最大值为15分,最小值为3分,治疗前后评分改善最高达11分,根据疗效评价标准5例无效,显效25例,有效率达83.33%;3.中医症候评分情况:治疗前中医症候评分在20.68±2.36分,最高24分,最低16分,治疗四周后在9.73±5.41分,最高21分,最低6分,治疗前后分差最低1分,最高达18分,疗效评价显效5例,有效21例,无效4例,治疗前后(P0.01)有明显差异,有效率达86.67%。4.实验期间失访1例患者,另2例患者因妻子早孕无法房事脱落,后续重新收集3例补齐。30例患者除1例诉服药期间偶有胃脘不适、大便偏稀外,余患者未出现明显不良反应。结论:加味桂精汤对于肝肾阴虚型早泄患者有较好的临床疗效,且安全可靠,其不仅延长了患者射精潜伏时间,增强患者自信心,促进夫妻生活和谐,更重要的是改善患者身体状况,增强体质,多角度、全方位地达到治疗目的。
[Abstract]:Objective: to observe the effect of Jiawei Gui Jing decoction on prolonging ejaculation latency and improving symptoms. Methods 1. 30 patients with premature ejaculation of liver-kidney yin deficiency type were selected from the department of andrology of the people's Hospital affiliated to Fujian University of traditional Chinese Medicine, which met the criteria for the inclusion of premature ejaculation of liver and kidney yin deficiency type. All of them signed informed consent, aged between 22 and 55 years, with an average age of 36.53 卤7.98 years. The clinical trial design was carried out by self-control method .2.The patients were given oral treatment of Jiawei Gui Jing decoction once a day, each dose was taken twice for 4 weeks. According to the patient's own condition, at least once a week during the period of taking medicine. According to the patient's return visit, observe the clinical curative effect at four time points, before the treatment, The ejaculation latency time of 1 week, 2 weeks and 4 weeks after treatment (if there is only one life record time in one week, if there are multiple mean values, the diagnosis scale of premature ejaculation, the changes of TCM symptoms, etc.). The changes of ejaculation latency time (IELTT): before treatment, the IELT of patients was in the range of 91.03 卤10.44 seconds, the maximum value was 106.00 seconds, the minimum value was 71.89 seconds, and after four weeks treatment, it was in the range of 242.75 卤88.50 seconds, and the maximum value was 410.84 seconds. The minimum value was 76.45 seconds. The IELT of 5 patients was no longer than that of before treatment, while the other 25 patients had a different degree of prolongation, the maximum value was 307.04 seconds. There was significant difference in the values before and after treatment (P 0.01). The effective rate was 83.33 and 2.The score of PEDTs of patients with premature ejaculation was 13.27 卤1.44 before treatment, the maximum value was 16 points, the minimum value was 10 points, the maximum value was 5.97 卤3.15 after four weeks treatment, the maximum value was 15 points, the minimum value was 3 points. Before and after treatment, the highest score was 11 points, according to the evaluation criteria of curative effect, 5 cases were ineffective, 25 cases had remarkable effect, and the effective rate was 83.33 and 3.The TCM symptom score was 20.68 卤2.36 points before treatment, the highest score was 24 points, and the lowest was 16 points. After four weeks of treatment, the scores were 9.73 卤5.41, the highest was 21, the lowest was 6, the difference before and after treatment was the lowest and the highest was 18. There were significant differences in the evaluation of curative effect in 5 cases, effective in 21 cases, ineffective in 4 cases, and before and after treatment (P 0.01). The effective rate was up to 86.67.4.One patient was not interviewed during the experiment, the other two patients were unable to have sex because of their wife's early pregnancy. In the follow-up, 3 cases were collected again. 30 cases were collected again, except for one case who complained of epigastric discomfort and dilute stool during the period of taking medicine. Conclusion: Jiawei Gui Jing decoction has good clinical effect on premature ejaculation of liver and kidney yin deficiency type, and it is safe and reliable. It not only prolongs the latent time of ejaculation, but also enhances the self-confidence of the patients. To promote the harmonious life of husband and wife, it is more important to improve the patients' physical condition, strengthen their physique, and achieve the purpose of treatment in all directions.
【学位授予单位】：福建中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R277.5

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