加巴喷丁治疗带状疱疹后神经痛对患者细胞免疫功能的影响

发布时间：2018-03-12 20:22

本文选题：加巴喷丁　切入点：带状疱疹后　出处：《广西医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的探讨加巴喷丁治疗带状疱疹后神经痛对患者细胞免疫功能的影响。方法选择符合纳入标准的37例带状疱疹后神经痛患者作为研究对象,以前后自身对照为实验方法。患者入院后口服加巴喷丁胶囊,加巴喷丁采用快速滴定给药方法,在第6天总剂量达到1800mg/d,同时每日给予止痛药氨酚羟考酮片0.5片,3次/d,每日给予抗抑郁药氟哌噻吨美利曲辛片1片,1次/d。治疗第7天后以1800mg加巴喷丁每日维持治疗,不再使用氨酚羟考酮和氟哌噻吨美利曲辛片。分别于治疗前(T0),治疗第7天(T1),治疗第14天(T2),治疗第21天(T3)抽取患者外周静脉血,测量CD4+T淋巴细胞、CD8+T淋巴细胞亚群,计算CD4+/CD8+的比值以及记录各个时点的NRS评分。结果1、治疗后的PHN患者NRS评分随时间变化均呈下降趋势,差异有统计学意义(P0.05)。2、细胞免疫指标比较:患者治疗后CD4+T淋巴细胞以及CD4+/CD8+比值升高,差异有统计学意义(P0.05),CD8+T淋巴细胞亚群未见变化,差异无统计学意义(P0.05)。结论初次使用加巴喷丁治疗PHN患者3周,能提高患者细胞免疫功能。
[Abstract]:Objective to investigate the effect of gabapentin on cellular immune function in patients with postherpetic neuralgia. The patients were treated with gabapentin capsule after admission, and gabapentin was administered by rapid titration. On the sixth day, the total dose reached 1800 mg / d, and the analgesic acetaminophen hydroxycodone was given 0.5 tablets per day three times a day, and the antidepressant droperazothioate meritriaxine was given one tablet per day once a day. After 7 days of treatment, it was maintained with 1800 mg of gabapentine daily. Paracetamol hydroxycodone and droperazothioate melitracin tablets were no longer used. The peripheral venous blood was extracted from patients with CD4 T lymphocyte and CD8 T lymphocyte subsets on day 7, day 14, day 14, day 21, respectively. Calculated the ratio of CD4 / CD8 and recorded the NRS score at each time point. Results 1. The NRS score of PHN patients after treatment showed a downward trend with time. The difference was statistically significant (P 0.05). Comparison of cellular immune indexes: after treatment, CD4 T lymphocytes and the ratio of CD4 / CD8 increased, the difference was statistically significant (P 0.05) and CD8 T lymphocyte subsets did not change. Conclusion the initial treatment with gabapentine for 3 weeks can improve the cellular immune function of PHN patients.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R752.12

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