早孕期超声检查胎儿神经系统及心血管系统重要参数研究

发布时间：2018-03-26 01:51

本文选题：早孕期　切入点：超声　出处：《吉林大学》2017年硕士论文

【摘要】：第一部分早孕期超声检查胎儿神经系统重要参数研究目的:制定早孕期各孕龄(天)对应颅内透明层厚度(intracranial translucency,IT)的正常值范围,研究IT值与孕龄(天)、头臀径(Crown-Rump Length,CRL)、孕妇年龄及颈项透明层厚度(nuchal translucency,NT)的相关性及IT值用于筛查神经系统畸形的临床意义。资料与方法:选取2013年10月至2014年12月到吉林大学第二医院门诊产前诊断中心就诊的385例孕妇,孕妇年龄22~42岁,平均年龄(30.76±3.89)岁,胎儿孕龄11~14孕周。排除孕期检查发现或可疑的解剖学异常,遗传学异常,NT增厚,出生后随访出现异常的胎儿后,共入选355例孕妇,搜集整理所有入选病例报告单并记录IT值,采用回顾性分析法,应用SPSS20.0统计软件进行统计学分析。结果:1、制定12~(+1)~14孕周各孕龄(天)对应IT值的正常值范围。2、IT值与孕龄(天)呈正相关(p-value0.01),随其增加呈线性增加。3、IT值与CRL呈正相关(p-value0.01),随其增加呈线性增加。4、IT值与孕妇年龄无相关性(p-value0.01)。5、IT值与NT值呈正相关(p-value0.01)。结论:本研究制定了早孕期各孕龄(天)对应IT值的正常值范围,发现IT值随孕龄(天)、CRL、NT值的增加而增加,并探讨IT值用于筛查神经系统异常的临床意义。第二部分早孕期超声检查胎儿心血管系统重要参数研究目的:制定早孕期各孕龄(天)对应颈项透明层厚度、心轴、心率的正常值范围,分别研究NT值、心轴、心率与孕龄(天)、CRL、孕妇年龄的相关性,并研究NT值、心轴、心率、心内强回声、静脉导管血流频谱、三尖瓣血流用于筛查心血管系统异常的临床意义。资料与方法:选取2013年10月至2014年12月到吉林大学第二医院门诊产前诊断中心就诊的385例孕妇,孕妇年龄22~42岁,平均年龄(30.76±3.89)岁,胎儿孕龄11~14孕周。按排除标准排除后,共入选355例孕妇,搜集整理所有入选病例报告单并记录相关数据,采用回顾性分析法,应用SPSS20.0统计软件进行统计学分析。结果:1、制定12~(+1)~14孕周各孕龄(天)对应NT值、心轴、心率的正常值范围。2、NT值与孕龄(天)呈正相关(p-value0.01),随其增加呈线性增加;与CRL呈正相关,随其增加呈线性增加(p-value0.01);与孕妇年龄无相关性(p-value0.01)。3、心轴与孕龄(天)无相关性(p-value0.01);与CRL无相关性(p-value0.01);与孕妇年龄无相关性(p-value0.01)。4、心率与孕龄(天)呈负相关(p-value0.01),随其增加逐渐减小;与CRL呈负相关,随其增加逐渐减小(p-value0.01);与孕妇年龄无相关性(p-value0.01)。结论:本研究制定了早孕期各孕龄(天)对应NT值、心轴、心率的正常值范围,发现三者与孕龄(天)、CRL、孕妇年龄的相关性,并阐述了NT值、心轴、心率、心内强回声、静脉导管血流频谱、三尖瓣血流筛查心血管系统异常的临床意义,有助于先天性心脏病早期发现,规范监护,尽早处理,以减少缺陷儿出生提高人口素质。
[Abstract]:Part I study on the important parameters of fetal nervous system in early pregnancy objective: to determine the normal range of the thickness of the transparent layer of the brain corresponding to the thickness of the translucent layer of the brain in each gestational age (day) during the early pregnancy. To study the correlation between IT value and gestational age (Crown-Rump Lengthia, age of pregnant women and thickness of transparent layer of neck) and the clinical significance of IT value in screening nervous system malformations. Data and methods: from October 2013 to December 2014, the clinical significance of IT value in screening nervous system malformations was studied. 385 pregnant women in the outpatient antenatal diagnosis center of the second Hospital of Jilin University, The pregnant women were 22 ~ 42 years old with an average age of 30.76 卤3.89 years, and the gestational age of the fetus was 11 ~ 14 weeks. All the selected report forms were collected and the IT values were recorded. SPSS20.0 statistical software was used to carry out statistical analysis. Results: 1: 1, the normal range of IT value corresponding to each gestational age (day) of 14 weeks of gestation was determined. 2IT value was positively correlated with gestational age (day). With the increase of IT value, there was a positive correlation between IT value and CRL. There was no correlation between the value of IT and the age of pregnant women. There was a positive correlation between the value of IT and the value of NT. Conclusion: this study established the normal range of IT values for each gestational age (day) in early pregnancy. It was found that the IT value increased with the increase of gestational age (CRLN NT value). To explore the clinical significance of IT value in screening nervous system abnormalities. Part two important parameters of fetal cardiovascular system in early pregnancy objective: to determine the thickness of cervical clear layer and cardiac axis in different gestational ages during early pregnancy. The normal range of heart rate, NT value, cardiac axis, heart rate and gestational age (CRL) were studied, and NT value, cardiac axis, heart rate, intracardiac strong echo, venous blood flow spectrum were studied. Clinical significance of tricuspid blood flow in screening cardiovascular abnormalities data and methods: 385 pregnant women, aged 2242 years, were selected from October 2013 to December 2014 in the outpatient prenatal diagnosis center of the second Hospital of Jilin University. The average age was 30.76 卤3.89 years, and the gestational age of the fetus was 1114 weeks. According to the exclusion criteria, 355 pregnant women were selected to collect all the selected case reports and record the relevant data. SPSS20.0 statistical software was used to carry out statistical analysis. Results at 1: 1, the corresponding NT values for each gestational age (day) of 14 weeks of gestation were determined. The normal value range of heart axis and heart rate was positively correlated with gestational age (day), and the value of value increased linearly with the increase of gestational age (day), and positively correlated with CRL. There was no correlation between p-value0.01n and gestational age (day), and there was no correlation between cardiac axis and gestational age (day). There was no correlation between p-value0.01g and CRL, and there was no correlation between p-value0.01n and gestational age (day). The heart rate was negatively correlated with gestational age (day), and decreased gradually with the increase of gestational age (day). There was a negative correlation with CRL, which decreased gradually with the increase of CRL, and had no correlation with the age of pregnant women. Conclusion: the normal range of NT value, cardiac axis and heart rate for each gestational age (day) in early pregnancy period was established in this study. The clinical significance of NT value, cardiac axis, heart rate, intracardiac strong echo, venous catheter blood flow spectrum and tricuspid blood flow screening for abnormal cardiovascular system were discussed. It is helpful for early detection of congenital heart disease, standardized monitoring, early treatment, in order to reduce birth defects and improve the quality of the population.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R714.5;R445.1

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