青海地区非酒精性脂肪肝病患者血清γ-GT、CHE、IR水平测定及临床意义

发布时间：2018-04-02 20:51

  本文选题：非酒精性脂肪肝　切入点：γ-谷氨酰转肽酶　出处：《青海大学》2017年硕士论文

【摘要】：目的:通过检测青海地区非酒精性脂肪性肝病(Nonalcoholic fatty liver disease,NAFLD)患者血清γ-谷氨酰转移酶(γ-GT)、胆碱酯酶(CHE)和胰岛素抵抗指数(IR),探讨其对诊断NAFLD的预测价值。方法:1.收集我院消化内科于2015年11月到2016年11月诊断为非酒精性脂肪肝的患者73例,以同期在体检中心体检的正常健康者77例作为对照。2.非酒精性脂肪肝通过腹部CT检查明确,两组均测定血清葡萄糖、血脂和肝功能及血清胰岛素水平。通过稳态模型评价(HOMA)计算HOMA-IR(IR)、HOMA-IS和HOMAβ。结果:1.NAFLD组BMI、ALT、TG、FBG、γ-GT和HOMA-IR水平高于正常对照组,有统计学差异(P0.05),HOMA-IS水平低于正常对照组,有统计学差异(P0.05),CHE、HOMAβ比较无统计学差异(P0.05)。2.γ-GT(OR=1.235,P0.05)和HOMA-IR(OR=17.247,P0.05)都是NAFLD的独立危险因素。3.HOMA-IR预测NAFLD的最佳切点值为1.76,敏感度为78.1%,特异度为64.9%;同理γ-GT最佳切点值为24.7U/L,敏感度为56.2%,特异度为83.1%。结论:1.青海地区非酒精性脂肪肝患者血清中γ-GT、IR、ALT、TG、FBG升高;HOMA-IS水平降低;而CHE、HOMAβ水平无差异;2.血清γ-GT和IR可作为预测NAFLD发生的独立危险因素,联合检测对NAFLD诊断有早期的预测价值。
[Abstract]:Objective: to investigate the predictive value of serum 纬 -glutamyl transferase (纬 -GT) and insulin resistance index (IRI) in patients with nonalcoholic fatty liver disease (NAF LDD) in Qinghai area.Method 1: 1.From November 2015 to November 2016, 73 cases of non-alcoholic fatty liver were diagnosed in the Department of Digestive Medicine of our hospital, and 77 cases of normal health checked in the same period were used as control.Non-alcoholic fatty liver was determined by abdominal CT. Serum glucose, blood lipid, liver function and serum insulin were measured in both groups.HOMA-IS and HOMA 尾 were calculated by steady-state model evaluation.Results 1. The levels of HOMA-IR, 纬 -GT and BMIT in NAFLD group were higher than those in normal control group, and the levels of HOMA-IS in NAFLD group were lower than those in normal control group.鏈夌粺璁″�﹀樊寮�(P0.05),CHE,HOMA尾姣旇緝鏃犵粺璁″�﹀樊寮�(P0.05).2.纬-GT(OR=1.235,P0.05)鍜孒OMA-IR(OR=17.247,P0.05)閮芥槸NAFLD鐨勭嫭绔嬪嵄闄╁洜绱，

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