低能量放散式体外冲击波针灸治疗原发性痛经的临床研究

发布时间：2018-04-17 21:05

本文选题：原发性痛经(Primary + Dysmenorrhea　；参考：《新疆医科大学》2017年硕士论文

【摘要】：目的:观察低能量放散式体外冲击波针灸治疗原发性痛经(Primary Dysmenorrhea,PD)的疗效以及治疗后对患者体内血清前列腺素E2(PGE2)、前列腺素F2α(PGF2α)浓度的影响或者改变,以期为临床治疗原发性痛经提供新的治疗方法、治疗思路。方法:招募原发性痛经患者20例作为试验组,未发生过痛经的女性20例作为提供正常血清前列腺素水平的对照组。试验组于月经排卵期前后1-2日,选取三阴交、足三里、关元穴位;腹直肌趾骨联合附着点、腹外斜肌等部位进行冲击波针灸治疗。将月经排卵期左右接受1次治疗视为1个疗程,治疗1个疗程后随访6个月并评估其治疗效果。试验组分别于治疗前后第1次月经来潮24-48小时内静脉采血;正常对照组于月经来潮24-48小时内静脉采血,测定血清前列腺素E2、血清前列腺素F2α的浓度,并比较二者在试验组接受治疗前后以及与提供正常血清前列腺素水平的对照组的浓度变化,并使用视觉模拟疼痛评分(Visual Analogue Scale,VAS)进行疼痛程度评定。结果:(1)1个治疗周期后试验组总有效率为80%(16/20)。试验组治疗后视觉模拟疼痛评分均值较治疗前降低(p0.001)。治疗后血清前列腺素E2浓度中位数(四分位间距)较治疗前显著增加(p0.05),治疗后血清前列腺素F2α浓度中位数(四分位间距)较治疗前明显降低(p0.05)。治疗后血清前列腺素E2、血清前列腺素F2α浓度与提供正常血清前列腺素水平的对照组的中位数(四分位间距)相比无统计学差异(p0.05)。结论:低能量放散式体外冲击波针灸循经取穴治疗,使阴阳归于平衡,降低原发性痛经患者经期血清前列腺素F2α浓度,提高血清前列腺素E2浓度,松解痉挛腹部肌肉从而达到减轻疼痛症状的目的,因此此方法值得在临床上学习并推广。
[Abstract]:Objective: to observe the effect of low energy release extracorporeal shock wave acupuncture and moxibustion on primary dysmenorrhea (PDD) and the effect or change of serum prostaglandin E 2 (PGE 2), prostaglandin F 2 伪 (PGF 2 伪) in patients with dysmenorrhea.In order to provide clinical treatment of primary dysmenorrhea to provide a new treatment, treatment ideas.Methods: twenty patients with primary dysmenorrhea and 20 women without dysmenorrhea were recruited as control group.The experimental group was treated with shock wave acupuncture on 1-2 days before and after menstrual ovulation, including Sanyinjiao, Zusanli, Guanyuan acupoints, the joint attachment point of rectus abdominis phalangeal bone and external oblique abdominal muscle.The period of menstrual ovulation was treated as a course of treatment, followed up for 6 months after one course of treatment, and the therapeutic effect was evaluated.In the experimental group, venous blood was collected within 24-48 hours of the first menstrual cycle before and after treatment, and in the normal control group, the concentration of prostaglandin E _ 2 and prostaglandin F _ 2 伪 was measured within 24-48 hours of menstruation.The changes of serum prostaglandin levels before and after treatment were compared between the two groups, and the pain degree was evaluated by visual analog pain score (VAS).Results after one treatment cycle, the total effective rate of the trial group was 80 / 16 / 20.The mean visual analogue pain score after treatment in the trial group was lower than that before treatment.After treatment, the median serum prostaglandin E _ 2 concentration (quartile spacing) increased significantly compared with that before treatment, and the median serum prostaglandin F _ 2 伪 concentration (quartile spacing) after treatment was significantly lower than that before treatment.After treatment, there was no significant difference in serum prostaglandin E _ 2, serum prostaglandin F _ 2 伪 concentration and the median (quartile spacing) between the normal serum prostaglandin level and the control group (P 0.05).Conclusion: low energy release extracorporeal shock wave acupuncture and moxibustion along meridian points can balance yin and yang, decrease serum prostaglandin F 2 伪 concentration and increase serum prostaglandin E 2 concentration in patients with primary dysmenorrhea.This method is worth studying and popularizing in clinic because of loosening abdominal muscles and relieving pain symptoms.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R246.3

【参考文献】