喘安糖浆对慢性阻塞性肺疾病稳定期的临床疗效及止咳、祛痰、解热作用的实验研究

发布时间：2018-05-29 10:13

本文选题：喘安糖浆 + 慢性阻塞性肺疾病　；参考：《湖北民族学院》2017年硕士论文

【摘要】：目的:探讨喘安糖浆对慢性阻塞性肺疾病的临床疗效及通过实验研究喘安糖浆的止咳、祛痰、解热作用。方法:临床疗效:纳入患者为利川市民族中医院自2016年1月到2017年1月期间住院病例,共58例。对照组和喘安组各29例,对照组懫用西医常规治疗,喘安组在西医常规治疗基础上加喘安糖浆口服治疗,观察对患者临床症状、体征、hsCRP、PCT、肺功能、动脉血气分析的影响。实验研究:小鼠50只,雌雄各半,按体重随机分成空白对照组、阳性药止咳橘红胶囊对照组(0.65g/kg)、喘安糖浆高剂量组(4.0g/kg)、喘安糖浆中剂量组(2.0g/kg)、喘安糖浆低剂量组(1.0g/kg),每组10只,采用氨水引咳法后观察5min中的咳嗽次数和咳嗽潜伏时间。小鼠50只,雌雄各半,实验分组、给药剂量同上,采用酚红祛痰法后观察对小鼠酚红排泄量的影响。取大鼠60只,雌雄各半,按体重随机分成喘安糖浆高(2.8g/kg)、中(1.4g/kg)、低剂量组(0.7g/kg)阳性药止咳橘红胶囊对照组(0.46g/kg)、模型组和空白组,采用内毒素致热法后观察对内毒素致大鼠发热的影响。结果:1.喘安组与对照组经3个月观察后比较,在咳嗽、咳痰、气短、自汗、水肿、腹胀6项中医证侯改善上有显著性差异(p0.05)。2.喘安组与对照组经3个月观察后比较,在咳嗽、咳痰量、痰液性质、咯痰难易、发热、湿罗音6项症状体征改善上有显著性差异(p0.05)。3.观察治疗三月后喘安组的肺功能指标FEV1、FEV1比预计值、FVC、FEV1比FVC比对照组有明显改善(p0.05)。4.观察治疗三月后喘安组的血气分析指标PaO2、PaCO2比对照组有明显改善(p0.05)。5.观察治疗14天后喘安组的hsCRP和PCT比对照组有明显改善(p0.05)。6.喘安糖浆剂高、中、低剂量组与空白组比,能明显的增加小鼠咳嗽的潜伏期和降低咳嗽次数。7.各给药组同空白对照组比较,喘安糖浆高、中、低剂量和阳性药对小鼠呼吸道酚红的排泄量有增加的趋势,说明喘安糖浆有一定的祛痰作用。8.各组动物给药前体温无明显差异性(p0.05),给致热剂后模型组的不同时间体温明显升高(p0.05)。不同时间各给药组分别同模型组比较,给致热剂后1h、2h、3h,各给药组体温明显降低(p0.05);给致热剂后4h喘安糖浆各组体温明显降低(p0.05),而阳性对照组无明显差异性(p0.05);给致热剂后5h,喘安糖浆高剂量组体温明显降低(p0.05);其他各组无明显差异性(p0.05),表明喘安糖浆可以抑制脂多糖引起的大鼠体温升高,作用时间达5小时以上,有明显解热作用。结论:提示喘安糖浆可改善COPD患者咳嗽、咳痰、气短、自汗、水肿、腹胀症候。喘安糖浆可改善COPD患者咳嗽、咳痰量、痰液性质、咯痰难易、发热、湿罗音症状体征。喘安糖浆可改善COPD稳定期患者的肺功能、血气分析指标、hsCRP和PCT。喘安糖浆口服给药可明显减少氨水引起的小鼠咳嗽次数、明显延长咳嗽潜伏期,具有止咳作用;可使小鼠呼吸道酚红排出量增加,具有祛痰作用;对脂多糖引起的大鼠发热有明显的抑制作用,具有解热作用。表明喘安糖浆具有止咳、祛痰、解热作用。
[Abstract]:Objective: To investigate the clinical effect of Chuan an syrup on chronic obstructive pulmonary disease and to study the effect of tuscking, expectorant and antipyretic effect through experimental study of pant syrup. Methods: the clinical efficacy of the patients was included in the patients from January 2016 to January 2017 in Lichuan national traditional Chinese medicine hospital. There were 58 cases in the control group and Chuan an group, and the control group was treated with western medicine. The effect of Chuan an group on the clinical symptoms, signs, hsCRP, PCT, lung function and arterial blood gas analysis was observed on the basis of traditional western medicine routine treatment. Experimental study: 50 mice were divided into blank control group according to weight, and the positive drug of antitussive orange red capsule control group (0.65g/kg) and high pant syrup were high. The dose group (4.0g/kg), the dose group (2.0g/kg) in pant syrup, and the low dose group (1.0g/kg) of pant syrup (1.0g/kg), the cough times and the latent time of coughing in 5min were observed after the cough method of ammonia water. In mice, 50 mice and male and male, the experimental group, the dose of the same, the effect of phenol red expectorant method on the excretion of phenol red in mice. 60 rats, male and female, were randomly divided into wheezing syrup high (2.8g/kg), middle (1.4g/kg), low dose group (0.7g/kg) positive antitussive orange red capsule control group (0.46g/kg), model group and blank group, the effect of endotoxin induced heat observation on endotoxin induced fever in rats. Results: 1. pantine group and control group were compared after 3 months' observation. There were significant differences in 6 TCM Syndromes of cough, expectoration, shortness of breath, self perspiration, edema and abdominal distention (P0.05). After 3 months of observation, there was a significant difference in cough, expectoration, sputum nature, phlegm difficulty, fever, and 6 symptoms of wet rales (P0.05).3. observation for the treatment of lung function in the group of Chuan an after March FEV1, FEV1, FVC and FEV1 were significantly better than those of the control group (P0.05) compared with the control group (P0.05).4. observation on the blood gas analysis index PaO2 after March, and PaCO2 significantly improved (P0.05).5. observation group (P0.05).5. observation after 14 days. Compared with the blank group, the latent period of coughing in mice and the decrease of the number of coughing.7. were significantly increased. The high, middle, low dose, and positive drugs had a tendency to increase the excretion of phenol red in the respiratory tract of mice, indicating that there was no obvious difference in body temperature before the administration of.8. in each group of animals. The body temperature of the model group was significantly increased (P0.05) at different time after the heat agent (P0.05). The body temperature of each group was significantly lower than that of the model group at different time. After giving the heat agent 1H, 2h, 3h, the body temperature of each group was significantly decreased (P0.05). After the heat agent, the body temperature of 4H panting syrup in 4H was decreased (P0.05), but there was no significant difference in the positive control group (P0.05); After 5h, the body temperature of the high dose group was obviously decreased (P0.05), and there was no significant difference in other groups (P0.05). The results showed that pasthmatic syrup could inhibit the temperature rise of rats induced by lipopolysaccharide for more than 5 hours, and there was an obvious antipyretic effect. Conclusion: Wheezing syrup can improve the cough, expectoration, shortness of breath, perspiration and edema in COPD patients. Pant syrup can improve the cough, expectoration, sputum, phlegm, phlegm, fever, and wet sound symptoms in COPD patients. Wheezing syrup can improve the lung function of patients in the stable period of COPD. The oral administration of hsCRP and PCT. pant syrup can obviously reduce the number of cough caused by ammonia water and prolong the latent period of cough. It has the effect of relieving cough. It can increase the excretion of phenol red in the respiratory tract of mice and have the effect of eliminating phlegm. It has obvious inhibitory effect on the fever caused by lipopolysaccharide in rats, and has the antipyretic effect. It shows that pant syrup has the effect of relieving cough, eliminating phlegm and antipyretic.
【学位授予单位】：湖北民族学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

【参考文献】