补体C1q对类风湿关节炎活动度诊断价值的临床研究

发布时间：2018-06-04 05:09

本文选题：补体C1q + 类风湿关节炎　；参考：《新疆医科大学》2017年硕士论文

【摘要】：目的:探讨血清补体C1q水平对类风湿关节炎活动度的诊断价值。方法:收集160例RA患者(活动组110例,缓解组50例)的外周静脉血,测定其血清补体C1q水平,同时检测与RA疾病活动度相关的指标ESR、hs-CRP、RF以及CCP的表达,并采用SPSS19.0软件进行比较分析。结果:RA患者活动组C1q、ESR、hs-CRP水平高于缓解组,且差异具有统计学意义(P0.05),ESR、hs-CRP与C1q具有相关性(P0.05);RA患者活动组RF阳性率高于缓解组(P0.05),CCP阳性率与缓解组无统计学差异(P0.05),C1q与RF具有相关性(P0.05)而与CCP没有相关性(P0.05);C1q、ESR、hs-CRP、RF与DAS28具有显著相关性(P0.05),CCP与DAS28相关性不显著。补体C1q诊断RA患者活动期的ROC曲线下面积为0.87,最佳截断值为224.5mg/l,此时灵敏度为0.81,特异度为0.80。C1q诊断RA患者活动期的灵敏度为0.71,特异度为0.80,Youden指数为50.9,阳性似然比为3.5,阴性似然比为0.36。将C1q、ESR、hs-CRP、RF四项指标联合试验,得出灵敏度为0.87,特异度为0.92,正确指数为0.79,Kappa值0.65。结论:血清补体C1q可以作为评价RA活动度的指标,C1q、ESR、hs-CRP、RF四项指标联合检测对诊断RA活动度的价值比单独任一指标的诊断价值高。
[Abstract]:Objective: to investigate the diagnostic value of serum complement C 1q level in rheumatoid arthritis (RA). Methods: peripheral venous blood was collected from 160 RA patients (active group 110 cases, remission group 50 cases), and serum complement C1q level was measured. The expression of ESRHs-CRPnP RF and CCP related to disease activity of RA was detected at the same time. SPSS19.0 software is used to compare and analyze. Results the levels of ESRHs-CRP in the active group of patients with 0: RA were higher than those in the remission group. The positive rate of RF in the active group was higher than that in the remission group. There was no significant difference between P0.05C1q and RF (P0.05). There was no correlation between P0.05Hs-CRP and CCP, but there was no significant correlation between P0.05ESRHs-CRP1q and DAS28 in patients with RA. The correlation between CCP and DAS28 was not significant. The area under the ROC curve of complement C1q was 0.87, the best truncation value was 224.5 mg / l, the sensitivity was 0.81, the specificity was 0.71, the specificity was 0.80 Youden index 50.9, the positive likelihood ratio was 3.5, and the negative likelihood ratio was 0.366.The specificity was 0.71, the specificity was 0.80 Youden index, the positive likelihood ratio was 3.5, and the negative likelihood ratio was 0.361.The sensitivity was 0.71, the specificity was 0.80 Youden index, the positive likelihood ratio was 3.5, and the negative likelihood ratio was 0.36. The results showed that the sensitivity was 0.87, the specificity was 0.92, and the correct index was 0.79 Kappa value. Conclusion: serum complement C1q can be used as an index to evaluate the activity of RA. The diagnostic value of serum complement C1q in diagnosing RA activity is higher than that of any single index.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R593.22

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