多囊卵巢综合征（痰湿证）伴高雄激素血症患者的临床特征分析

发布时间：2018-06-15 03:22

本文选题：多囊卵巢综合征 + 痰湿证　；参考：《黑龙江中医药大学》2017年硕士论文

【摘要】：目的:本研究通过对270例多囊卵巢综合征痰湿证患者和62例健康女性的一般临床特征及生化指标进行分析,探讨PCOS痰湿证伴高雄激素血症患者的临床特征,以期为疾病的个性化诊治及远期并发症的预防提供依据。方法:收集2014年12月至2017年2月黑龙江中医药大学附属第一医院临床科研信息一体化系统中270例PCOS痰湿证患者,根据T及AND水平将PCOS痰湿证患者分为痰湿证PCOS+HA组、痰湿证PCOS+non-HA组,选择同期就诊于本院体检中心的健康女性62例作为对照组。采集并记录三组受试者的一般临床信息、性腺激素、雄激素、糖脂等实验室指标,运用SPSS19.0统计软件进行分析。结果:(1)与对照组比较,痰湿证PCOS+HA组和痰湿证PCOS+non-HA组的初潮年龄、WC、DBP,痤疮、黑棘皮、溢脂及多毛的发生率显著增高,差异有统计学意义(P0.05)。痰湿证PCOS+HA组的多毛发生率显著高于痰湿证PCOS+non-HA组,痰湿证PCOS+HA的体重显著高于对照组,差异有统计学意义(P0.05)。三组年龄、BMI、身高、WHR、SBP差异无统计学意义(P0.05),但三组均表现为肥胖,且为腹型肥胖;(2)与对照组比较,痰湿证PCOS+HA组的FSH显著降低而DHEAS显著升高;痰湿证PCOS+non-HA 组的 FSH、SHBG 显著降低,DHEAS、LH、LH/FSH 值显著升高,差异有统计学意义(P0.05)。痰湿证PCOS+HA组的LH、LH/FSH、AND及T值显著高于痰湿证PCOS+non-HA组和对照组,SHBG水平显著低于痰湿证PCOS+non-HA组和对照组,差异有统计学意义(P0.05);(3)与对照组相比,痰湿证PCOS+non-HA组的TG、LDL、APOB及APOB/APOA值显著升高,痰湿证PCOS+HA组的APOB及APOB/APOA显著高,差异有统计学意义(P0.05)。痰湿证PCOS+HA组的TC、TG、LDL值显著高于痰湿证PCOS+non-HA组和对照组,差异有统计学意义(P0.05)。三组HDL及APOA差异无统计学意义(P0.05);(4)痰湿证PCOS+HA组的FPG、FINS、HOMA-IR值均显著高于痰湿证PCOS+non-HA组及对照组,差异有统计学意义(P0.05)。与对照组比较,痰湿证PCOS+non-HA组的FINS和HOMA-IR值显著升高,差异有统计学意义(P0.05)。结论:(1)多囊卵巢综合征痰湿证合并HA患者多毛发生率较高;(2)多囊卵巢综合征痰湿证合并HA患者性激素代谢异常较重;(3)多囊卵巢综合征痰湿证合并HA患者糖脂代谢紊乱较重。
[Abstract]:Objective: to study the clinical features and biochemical indexes of 270 patients with phlegm dampness syndrome and 62 healthy women with PCOS phlegm dampness syndrome and hyperandrogenemia. In order to provide basis for individualized diagnosis and treatment of disease and prevention of long-term complications. Methods: 270 PCOS patients with phlegm dampness syndrome were collected from December 2014 to February 2017 in the first affiliated Hospital of Heilongjiang University of traditional Chinese Medicine. According to the levels of T and, PCOS patients with phlegm dampness syndrome were divided into phlegm dampness syndrome PCOS HA group. Patients with phlegm dampness syndrome PCOS non-HA group were selected as control group. The clinical data of the three groups were collected and recorded. The laboratory indexes of gonadal hormone androgen sugar and lipid were analyzed by SPSS 19.0 software. Results compared with the control group, the incidence of menarche age in phlegm dampness syndrome PCOS HA group and phlegm dampness PCOS non-HA group was significantly higher than that in control group (P 0.05). The incidence of hirsutism in phlegm dampness syndrome PCOS HA group was significantly higher than that in phlegm dampness syndrome PCOS non-HA group, and the weight of phlegm dampness syndrome PCOS HA group was significantly higher than that of control group (P 0.05). There was no significant difference in BMIand WHRS-SBP among the three groups, but all of the three groups were obese, and were abdominal obesity.) compared with the control group, the FSH of the phlegm-dampness syndrome PCOS HA group was significantly lower and the DHEAS significantly higher than that of the control group. In PCOS non-HA group of phlegm-dampness syndrome, the SHBG of FSHS significantly decreased and the value of LHH / FSH in DHEASA was significantly higher than that in PCOS non-HA group, and the difference was statistically significant (P 0.05). The levels of LHH / FSHAND and T in phlegm dampness syndrome PCOS group were significantly higher than those in phlegm dampness syndrome PCOS non-HA group and control group. The levels of SHBG in phlegm dampness syndrome PCOS non-HA group and control group were significantly lower than those in phlegm dampness syndrome PCOS non-HA group and control group. The APOB and APOB / APOA of PCOS HA group with phlegm dampness syndrome were significantly higher than those of PCOS HA group (P 0.05). Compared with non-HA group and control group in phlegm-dampness syndrome PCOS group, the TCU TGN LDL value in PCOS HA group was significantly higher than that in PCOS non-HA group and control group in phlegm-dampness syndrome group, the difference was statistically significant (P 0.05). There was no significant difference in HDL and APOA among the three groups (P 0.05). The FINSHOMA-IR of phlegm dampness syndrome PCOS HA group was significantly higher than that of phlegm dampness syndrome PCOS non-HA group and control group (P 0.05). Compared with control group, fins and HOMA-IR in PCOS non-HA group of phlegm-dampness syndrome were significantly higher than those in control group (P 0.05). Conclusion (1) the incidence of polytrichoresis in patients with phlegm dampness syndrome combined with HA is higher than that in patients with polycystic ovary syndrome. (2) abnormal sex hormone metabolism in patients with phlegm dampness syndrome combined with HA is more serious than that in patients with polycystic ovary syndrome (PCOS) phlegm dampness syndrome with HA is more serious in the disorder of glucose and lipid metabolism in patients with polycystic ovary syndrome.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R271.9

【相似文献】