奔豚汤加减治疗儿童多发性抽动症（气郁化火型）的临床观察

发布时间：2018-08-18 10:59

【摘要】：目的:观察奔豚汤加减治疗气郁化火型多发性抽动症的临床疗效及安全性。方法:选取符合本研究标准的60例多发性抽动症患儿随机分成治疗组和对照组各30例。治疗组给予中药奔豚汤加减口服;对照组给予西药盐酸硫必利片口服。治疗2个月后,观察治疗前后两组临床症状变化、血常规、尿常规、肝功及肾功等。结果:两组治疗前后症状总积分组内比较,均P0.01,差异有统计学意义,说明治疗组与对照组均有显著疗效;两组总积分疗效比较,治疗组的总有效率为96.67%,对照组的总有效率为86.67%,两组进行比较,P0.01,具有显著差异,表明治疗组总积分疗效优于对照组;两组治疗前后在运动性抽动方面的疗效比较,治疗组运动性抽动的有效率为96.67%,对照组运动性抽动的有效率为90.00%,两组进行比较,P0.01,差异具有统计学意义,表明治疗组在运动性抽动方面的疗效明显优于对照组的疗效;两组治疗前后在发声性抽动方面的疗效比较,治疗组发声性抽动的总有效率为93.33%,对照组发声性抽动的总有效率为86.67%,两组进行比较,P0.05,差异具有统计学意义,表明治疗组在发声性抽动方面的疗效明显优于对照组的疗效;在治疗期间,治疗组未见不良反应,治疗后,治疗组安全性指标检查无异常,表明奔豚汤加减治疗多发性抽动症未见不良反应。结论:1.奔豚汤加减对气郁化火型多发性抽动症有显著疗效,且总体疗效优于盐酸硫必利;2.奔豚汤加减对运动性、发声性抽动的疗效均优于盐酸硫必利;3.奔豚汤加减对中医证候改善情况效果优于盐酸硫必利;4.奔豚汤加减治疗气郁化火型多发性抽动症未见不良反应。
[Abstract]:Objective: to observe the clinical efficacy and safety of Banxue decoction in the treatment of Qi-stagnation-fire-type multiple tic syndrome. Methods: 60 children with multiple tic syndrome were randomly divided into treatment group (n = 30) and control group (n = 30). The treatment group was treated with Bentou decoction and the control group with tiapride hydrochloride. After 2 months of treatment, the changes of clinical symptoms, blood routine, urine routine, liver function and renal function were observed before and after treatment. Results: there was significant difference between the two groups before and after treatment, which indicated that the treatment group and the control group had significant curative effect, and the total integral effect was compared between the two groups. The total effective rate of the treatment group was 96.67 and the total effective rate of the control group was 86.67. There was a significant difference between the two groups, which indicated that the total integral effect of the treatment group was better than that of the control group. The effective rate of exercise twitching in the treatment group was 96.67 and that in the control group was 90.0.The difference between the two groups was statistically significant, which indicated that the curative effect of the treatment group was obviously better than that of the control group. The total effective rate of vocal twitch was 93.33 in the treatment group and 86.67 in the control group. The difference between the two groups was statistically significant. The results showed that the therapeutic effect of the treatment group in vocal twitch was better than that of the control group, and during the treatment period, there was no adverse reaction in the treatment group, and after treatment, the safety index of the treatment group was not abnormal. It is indicated that Banyu decoction has no adverse reaction in the treatment of multiple tic syndrome. Conclusion 1. Bentanyou decoction has significant curative effect on qi stagnation and fire type multiple tic syndrome, and the overall curative effect is better than that of thiapride hydrochloride 2. The therapeutic effect of Bentanyu decoction on motor and vocal twitching was better than that of thiapride hydrochloride 3. The effect of Bandou decoction on the improvement of TCM syndromes was better than that of thiapride hydrochloride 4. There is no adverse reaction in the treatment of qi stagnation and fire type multiple tic syndrome by Bentou decoction.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R277.7

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