加味清营汤治疗气营两燔型川崎病的临床疗效研究
发布时间：2018-10-15 16:09
【摘要】：目的:应用加味清营汤联合常规西医疗法治疗气营两燔型的川崎病,记录患儿治疗前后检验指标以及临床症状,并与单纯西医治疗组相对照,观察中西医结合治疗川崎病的临床疗效及安全性,研究治疗川崎病的中西医结合优势,为中西医结合治疗川崎病提供临床依据及参考,从而优化川崎病的治疗方案。方法:选取符合中西医诊断标准及纳入标准的6个月至14岁气营两燔型的川崎病患儿60例,采用简单随机化方法分成两组,其中治疗组30例,对照组30例。两组在急性期(发热的第5～9天)均予静脉人免疫球蛋白2g/(kg · d)静滴,10～12小时输入。阿司匹林60mg/(kg·d),分3次口服,热退后减量为5mg/(kg·d),1次顿服,共服用7天。治疗组同时配合加味清营汤口服,治疗7天。采集两组患儿治疗前后检验指标:白细胞、C反应蛋白、血沉、血小板及治疗前后主要症状症候积分、发热时间。将所有数据录入计算机,应用SPSS21.0统计软件进行统计学分析,比较两组患儿采用不同治疗方案后主要症状症候积分、发热时间及实验室数据,以P0.05为差异有统计学意义,以P0.01为有显著差异。结果:1.临床症状比较:治疗后两组主要症状症候总积分与治疗前比较P0.01,差异有统计学意义,即治疗后两组主要症状均有明显改善。治疗后治疗组目赤、咽红、皮疹及四肢硬肿症候积分与对照组比较P0.05,差异有统计学意义,即治疗组在改善目赤、咽红、皮疹及四肢硬肿方面优于对照组。治疗组发热时间与对照组比较P0.05,差异有统计学意义,即治疗组在减少发热时间上比对照组有优势。2.检验指标比较:治疗后两组白细胞、C反应蛋白、血沉、血小板均有改善作用,且治疗组明显优于对照组(P0.01)。3.临床疗效评价比较:治疗组总有效率为93.33%;对照组总有效率为70.00%,在临床疗效上治疗组优于对照组(P0.05)。结论:加味清营汤联合常规西医疗法治疗气营两燔型的川崎病患儿,可降低炎症指标及血小板计数,改善主要临床症状,总疗效优于对照组。
[Abstract]:Objective: to use Jiawei Qingying decoction combined with routine western medicine therapy to treat Kawasaki disease of Qiying two burnt type, and to record the test indexes and clinical symptoms before and after treatment, and to compare with the western medicine treatment group alone. To observe the clinical efficacy and safety of integrated traditional Chinese and western medicine in the treatment of Kawasaki disease, to study the advantages of integrated traditional Chinese and western medicine in the treatment of Kawasaki disease, to provide clinical basis and reference for the treatment of Kawasaki disease, and to optimize the treatment scheme of Kawasaki disease. Methods: 60 children with Kawasaki disease aged from 6 months to 14 years old were randomly divided into two groups: treatment group (n = 30) and control group (n = 30). Both groups were given intravenous human immunoglobulin (2g/ (kg d) intravenously at the acute stage (5 ~ 9 days of fever) for 10 ~ 12 hours. Aspirin 60mg/ (kg d), was given orally for 3 times, and 5mg/ (kg d), was taken once for 7 days. The treatment group was treated with Jiawei Qingying decoction for 7 days. WBC, C-reactive protein, erythrocyte sedimentation rate, platelet and the score of main symptoms and symptoms before and after treatment, febrile time were collected before and after treatment. All the data were entered into the computer, and the statistical analysis was carried out by SPSS21.0 software. The main symptom score, fever time and laboratory data were compared between the two groups after different treatment schemes. The difference was statistically significant with P0.05. There was significant difference in P0.01. The result is 1: 1. Comparison of clinical symptoms: after treatment, the total score of major symptoms in the two groups was significantly improved compared with that before treatment (P 0.01), that is, the main symptoms of the two groups were obviously improved after treatment. After treatment, the score of eye red, pharynx, rash and limb sclerema in the treatment group was significantly higher than that in the control group (P 0.05), that is, the treatment group was superior to the control group in improving the eye red, pharynx, rash and limb sclerema. The febrile time in the treatment group was significantly higher than that in the control group (P 0.05), that is, the treatment group had an advantage over the control group in reducing the febrile time. Comparison of test indexes: after treatment, WBC, C-reactive protein, erythrocyte sedimentation rate and platelet were improved in the two groups, and the treatment group was significantly better than the control group (P0.01). Comparison of clinical efficacy evaluation: the total effective rate of the treatment group was 93.33; the total effective rate of the control group was 70.00. the treatment group was superior to the control group in clinical efficacy (P0.05). Conclusion: Jiawei Qingying decoction combined with routine western medicine therapy for Kawasaki disease of Qiying two burnt type can reduce the inflammatory index and platelet count, improve the main clinical symptoms, the total curative effect is better than the control group.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R725.4
本文编号：2273065
[Abstract]:Objective: to use Jiawei Qingying decoction combined with routine western medicine therapy to treat Kawasaki disease of Qiying two burnt type, and to record the test indexes and clinical symptoms before and after treatment, and to compare with the western medicine treatment group alone. To observe the clinical efficacy and safety of integrated traditional Chinese and western medicine in the treatment of Kawasaki disease, to study the advantages of integrated traditional Chinese and western medicine in the treatment of Kawasaki disease, to provide clinical basis and reference for the treatment of Kawasaki disease, and to optimize the treatment scheme of Kawasaki disease. Methods: 60 children with Kawasaki disease aged from 6 months to 14 years old were randomly divided into two groups: treatment group (n = 30) and control group (n = 30). Both groups were given intravenous human immunoglobulin (2g/ (kg d) intravenously at the acute stage (5 ~ 9 days of fever) for 10 ~ 12 hours. Aspirin 60mg/ (kg d), was given orally for 3 times, and 5mg/ (kg d), was taken once for 7 days. The treatment group was treated with Jiawei Qingying decoction for 7 days. WBC, C-reactive protein, erythrocyte sedimentation rate, platelet and the score of main symptoms and symptoms before and after treatment, febrile time were collected before and after treatment. All the data were entered into the computer, and the statistical analysis was carried out by SPSS21.0 software. The main symptom score, fever time and laboratory data were compared between the two groups after different treatment schemes. The difference was statistically significant with P0.05. There was significant difference in P0.01. The result is 1: 1. Comparison of clinical symptoms: after treatment, the total score of major symptoms in the two groups was significantly improved compared with that before treatment (P 0.01), that is, the main symptoms of the two groups were obviously improved after treatment. After treatment, the score of eye red, pharynx, rash and limb sclerema in the treatment group was significantly higher than that in the control group (P 0.05), that is, the treatment group was superior to the control group in improving the eye red, pharynx, rash and limb sclerema. The febrile time in the treatment group was significantly higher than that in the control group (P 0.05), that is, the treatment group had an advantage over the control group in reducing the febrile time. Comparison of test indexes: after treatment, WBC, C-reactive protein, erythrocyte sedimentation rate and platelet were improved in the two groups, and the treatment group was significantly better than the control group (P0.01). Comparison of clinical efficacy evaluation: the total effective rate of the treatment group was 93.33; the total effective rate of the control group was 70.00. the treatment group was superior to the control group in clinical efficacy (P0.05). Conclusion: Jiawei Qingying decoction combined with routine western medicine therapy for Kawasaki disease of Qiying two burnt type can reduce the inflammatory index and platelet count, improve the main clinical symptoms, the total curative effect is better than the control group.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R725.4
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