缺血修饰白蛋白、心肌酶谱、超敏肌钙蛋白T在急性冠脉综合征危险分层中的研究
发布时间：2019-02-16 16:20
【摘要】：目的:通过对缺血修饰白蛋白(IMA)、天门冬氨酸氨基转移酶(AST)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、?-羟丁酸脱氢酶(HBDH)、超敏肌钙蛋白T(HSCTNT)血浆水平的研究,获取早期诊断急性冠脉综合征(ACS)及病情危险程度的生化指标。方法:病例组选取2012年4月至2016年11月在新疆医科大学附属中医医院心血管内科住院的ACS患者601例,通过GRACE(THE GLOBAL REGISTRY OF ACUTE CORONARY EVENTS)危险评分计算器进行危险分层:低危组226例、中危组227例高危组148人,另选取健康体检者190例作为对照组。分别对病例组与对照组进行上述生化标志物的检测与分析。结果:IMA在各危险分层组与对照组之间的比较有统计学意义(P0.05),低危组与高危组之间比较有统计学意义(P0.05)但中危组与低危组、高危组与中危组之间没有统计学意义(P0.05)。AST:低危组与对照组之间的比较没有统计学意义(P0.05),中危组与对照组、高危组与对照组之间的比较有统计学意义(P0.05),各危险分层组之间的比较有统计学意义(P0.05)CK:各危险分层组与对照组之间的比较有统计学意义(P0.05);低危组与中危组之间的比较没有统计学意义(P0.05),中危组与高危组、高危组与低危组之间的比较有统计学意义(P0.05)。CK-MB:各危险分层组与对照组之间的比较有统计学意义(P0.05),各危险分层组之间的比较有统计学意义(P0.05)LDH:各危险分层组与对照组之间的比较有统计学意义(P0.05),低危组与中危组、高危组与低危组之间有统计学意义(P0.05),中危组与高危组之间没有统计学意义(P0.05)。HBDH:各危险分层组与对照组之间的比较有统计学意义(P0.05),低危组与中危组没有统计学意义(P0.05),中危组与高危组、高危组与低危组之间有统计学意义(P0.05)。HSCTNT:各危险分层组与对照组之间的比较有统计学意义(P0.05),各危险分层组之间的比较有统计学意义(P0.05)。结论:(1)IMA、AST、CK、LDH、HBDH:在ACS早期诊断及危险分层中有一定的参考价值。(2)CK-MB、HSCTNT:其检测对ACS的早期诊断具有统计学意义(P0.05),对ACS的危险分层有统计学意义(P0.05)。
[Abstract]:Objective: to investigate the effects of ischemia modified albumin (IMA), aspartate aminotransferase (AST), creatine kinase (CK), creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH),?-hydroxybutyrate dehydrogenase) (HBDH), To study the plasma level of hypertroponin T (HSCTNT) and to obtain biochemical indexes for early diagnosis of acute coronary syndrome (ACS) (ACS) and the risk of acute coronary syndromes (ACS). Methods: from April 2012 to November 2016, a total of 601 ACS patients in the Department of Cardiovascular Medicine, affiliated Hospital of traditional Chinese Medicine, Xinjiang Medical University, were selected for risk stratification by GRACE (THE GLOBAL REGISTRY OF ACUTE CORONARY EVENTS) risk score calculator: 226 cases in low risk group. There were 227 cases in the middle risk group and 148 cases in the high risk group. 190 healthy persons were selected as the control group. The above biochemical markers were detected and analyzed in the case group and the control group respectively. Results: there were significant differences in IMA between the risk stratified group and the control group (P0.05), and between the low risk group and the high risk group (P0.05), but between the middle risk group and the low risk group. There was no significant difference between high risk group and middle risk group (P0.05) between low risk group and control group (P0.05). The comparison between the high risk group and the control group was statistically significant (P0.05), and the comparison between the risk stratification group and the control group was statistically significant (P0.05). There was no significant difference between the low risk group and the middle risk group (P0.05), but there was no significant difference between the middle risk group and the high risk group. The comparison between high risk group and low risk group was statistically significant (P0.05). The comparison between CK-MB: risk stratification group and control group was statistically significant (P0.05). The comparison between the risk stratification group and the control group was statistically significant (P0.05). There were significant differences between the LDH: risk stratification group and the control group (P0.05), the low risk group and the middle risk group. There was significant difference between the high risk group and the low risk group (P0.05), but there was no statistical significance between the middle risk group and the high risk group (P0.05). There was no significant difference between the low risk group and the middle risk group (P0.05), while the middle risk group and the high risk group had no statistical significance (P0.05). There was significant difference between high risk group and low risk group (P0.05) between). HSCTNT: risk stratification group and control group (P0.05), and between each risk stratification group had statistical significance (P0.05). Conclusion: (1) IMA,AST,CK,LDH,HBDH: has certain reference value in the early diagnosis and risk stratification of ACS. (2) the detection of CK-MB,HSCTNT: has statistical significance in the early diagnosis of ACS (P0.05). The risk stratification of ACS was statistically significant (P0.05).
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R541.4
本文编号：2424625
[Abstract]:Objective: to investigate the effects of ischemia modified albumin (IMA), aspartate aminotransferase (AST), creatine kinase (CK), creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH),?-hydroxybutyrate dehydrogenase) (HBDH), To study the plasma level of hypertroponin T (HSCTNT) and to obtain biochemical indexes for early diagnosis of acute coronary syndrome (ACS) (ACS) and the risk of acute coronary syndromes (ACS). Methods: from April 2012 to November 2016, a total of 601 ACS patients in the Department of Cardiovascular Medicine, affiliated Hospital of traditional Chinese Medicine, Xinjiang Medical University, were selected for risk stratification by GRACE (THE GLOBAL REGISTRY OF ACUTE CORONARY EVENTS) risk score calculator: 226 cases in low risk group. There were 227 cases in the middle risk group and 148 cases in the high risk group. 190 healthy persons were selected as the control group. The above biochemical markers were detected and analyzed in the case group and the control group respectively. Results: there were significant differences in IMA between the risk stratified group and the control group (P0.05), and between the low risk group and the high risk group (P0.05), but between the middle risk group and the low risk group. There was no significant difference between high risk group and middle risk group (P0.05) between low risk group and control group (P0.05). The comparison between the high risk group and the control group was statistically significant (P0.05), and the comparison between the risk stratification group and the control group was statistically significant (P0.05). There was no significant difference between the low risk group and the middle risk group (P0.05), but there was no significant difference between the middle risk group and the high risk group. The comparison between high risk group and low risk group was statistically significant (P0.05). The comparison between CK-MB: risk stratification group and control group was statistically significant (P0.05). The comparison between the risk stratification group and the control group was statistically significant (P0.05). There were significant differences between the LDH: risk stratification group and the control group (P0.05), the low risk group and the middle risk group. There was significant difference between the high risk group and the low risk group (P0.05), but there was no statistical significance between the middle risk group and the high risk group (P0.05). There was no significant difference between the low risk group and the middle risk group (P0.05), while the middle risk group and the high risk group had no statistical significance (P0.05). There was significant difference between high risk group and low risk group (P0.05) between). HSCTNT: risk stratification group and control group (P0.05), and between each risk stratification group had statistical significance (P0.05). Conclusion: (1) IMA,AST,CK,LDH,HBDH: has certain reference value in the early diagnosis and risk stratification of ACS. (2) the detection of CK-MB,HSCTNT: has statistical significance in the early diagnosis of ACS (P0.05). The risk stratification of ACS was statistically significant (P0.05).
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R541.4
【参考文献】
相关期刊论文 前10条
1 张彦昂;朱晓红;;心电图与冠脉造影检查在急性冠脉综合征诊断中的应用对比[J];河南医学研究;2016年03期
2 周艳丽;章静;王淑春;张建军;宋杨英;;床旁快速联合测定肌钙蛋白I、肌酸激酶同工酶和肌红蛋白诊断急性心肌梗死的临床价值[J];检验医学与临床;2015年21期
3 陈传华;马祥波;罗艳华;;探讨联合检测血清缺血修饰白蛋白、超敏肌钙蛋白T水平对心肌缺血相关疾病的诊断价值[J];医学检验与临床;2015年05期
4 辛增莲;杨丽;郭宇璇;彭辉;徐菲莉;;缺血修饰清蛋白和心型脂肪酸结合蛋白检测在不稳定性心绞痛诊断及危险分层中的应用[J];国际检验医学杂志;2015年16期
5 付英姿;安刚;吕红君;许建成;张传军;;肌钙蛋白I、肌酸激酶同工酶、肌红蛋白检测对急性冠脉综合征的诊断价值[J];中国老年学杂志;2015年15期
6 陈容梅;陈琬琼;黎志明;欧阳翠华;叶显明;李巧汶;;血浆脑钠肽、肌钙蛋白T水平在急性冠脉综合征危险分层的相关性研究[J];中国医药科学;2015年12期
7 肖华勇;聂滨;;肝素对肌酸激酶及其同工酶测定干扰评价[J];国际检验医学杂志;2015年09期
8 余平安;潘峰;;IMA及cTnI在早期诊断ACS病情评估中的价值[J];检验医学;2015年03期
9 刘振良;贾国渠;胡立禄;向乾才;;缺血修饰白蛋白与冠心病的关系[J];心血管病学进展;2015年02期
10 张宁;刘文娴;;不稳定型心绞痛患者血浆乳酸脱氢酶水平与冠状动脉病变程度的关系研究[J];中国全科医学;2015年07期
相关硕士学位论文 前1条
1 于晓丽;高敏肌钙蛋白T检测在心肌梗死中应用价值的研究[D];大连医科大学;2011年
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