新型萘酰亚胺类植物生长调节剂及螺环季酮酸类杀螨剂的合成与生物活性研究

发布时间：2018-11-18 14:25

【摘要】：本课题组创造性地将萘酰亚胺基团应用到植物生长调节剂领域,设计合成了一系列具有植物生长调节剂活性的衍生物。本文在实验室前期工作的基础上,采用萘乙酸等有机酸对萘酰亚胺进行了进一步的修饰与设计改造,设计合成了有机酸酯类、酰基硫脲类两个系列共11个新型化合物。有机酸酯类化合物具体结构如下:8种新型化合物在室内及田间有效试验中均表现出较好的调节植物生长的活性,具有一定的研究与市场开发价值。3个酰基硫脲类化合物结构如下:生物活性测试显示,3种化合物兼具植物生长调节与杀菌的双重活性,具有一定的实际应用价值与开发前景。螺螨酯与螺甲螨酯因其独特的作用机制与优异的杀螨活性一直是杀螨剂研究的热点。本文在分析文献的基础上,对螺螨酯与螺甲螨酯进行了结构改造,合成的新型化合物3-(2,4-二氯苯基)-2-氧-1-氧杂螺[4.5]癸-3-烯-4-基丁基-1-磺酸酯与3-(2,4,6-三甲基苯基)-2-氧-1-氧杂螺[4.4]壬-3-戊-烯-4-基丁基-1-磺酸酯均具有优良的杀螨活性。
[Abstract]:A series of derivatives with plant growth regulator activity were designed and synthesized by applying naphthalimide groups creatively to the field of plant growth regulators. In this paper, based on the previous work in laboratory, naphthalenimide was modified and modified with naphthalene acetic acid and other organic acids. Two series of organic acid esters and acyl thiourea were designed and synthesized. The specific structures of organic acid esters are as follows: eight new compounds have shown good plant growth regulation activities in both indoor and field experiments. The structures of three acyl thiourea compounds were as follows: bioactivity test showed that the three compounds had both plant growth regulation and bactericidal activity. It has certain practical application value and development prospect. Spiromites and spiromedes have been the focus of acaricide research because of their unique mechanism and excellent acaricidal activity. In this paper, based on the analysis of literature, the structural modification of spiromites and spiromedex was carried out. Synthesis of a novel compound 3- (2o 4-dichlorophenyl) -2-oxo-1-oxypo [4.5] deca-3-ene-4-butyl-1-sulfonic acid ester and 3- (2o 4), 6-trimethyl phenyl)-2-oxo-1-Oxysnail [4.4] non- 3-pentene-4-butyl- 1-sulfonic acid ester has excellent acaricidal activity.
【学位授予单位】：青岛科技大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：TQ450.1

【参考文献】