WONCA研究论文摘要汇编——结肠癌患者有症状复发和无症状复发的多中心队列研究

发布时间：2018-05-18 12:48

本文选题：结肠癌患者 + WONCA　；参考：《中国全科医学》2016年22期

【摘要】：目的对结肠癌根治术后的患者进行随访,以及时发现复发症状和异时肿瘤。根据荷兰相关治疗指南,确定典型复发症状及诊断方法。方法回顾性分析在荷兰某两家医院进行连续性治疗结肠癌患者的临床资料,以2007年1月—2012年12月行结肠癌根治术的446例患者为研究对象,并对复发的74例患者进行进一步分析。结果 43例(58%)复发患者是在定期随访过程中发现,其中41例(95%)为无症状复发,肿瘤标志物检测、影像学检查及肠镜检查均显示有复发迹象。其余31例(42%)复发患者是在不定期间隔随访过程中发现,其中26例(84%)为有症状复发,典型临床症状为腹痛、排便异常及体质量减轻。无症状复发患者的存活率高于有症状复发患者。结论 42%的复发患者在不定期间隔随访过程中发现,主要依靠典型临床症状,初级保健医生应加强对复发率较高结肠癌患者的典型复发症状监测。
[Abstract]:Objective to follow up the patients after radical resection of colon cancer to detect recurrent symptoms and abnormal tumors in time. According to the relevant treatment guidelines in the Netherlands, to determine the typical recurrence symptoms and diagnostic methods. Methods the clinical data of patients with colon cancer undergoing continuous treatment in two hospitals in the Netherlands were retrospectively analyzed. 446 patients undergoing radical resection of colon cancer from January 2007 to December 2012 were studied. Further analysis was made on 74 cases of recurrence. Results Forty-three patients with recurrence were found to be asymptomatic recurrence in the course of regular follow-up, among them 41 cases were asymptomatic recurrence, tumor marker detection, imaging examination and enteroscopy showed signs of recurrence. The other 31 patients with recurrence were found in the course of random interval follow-up, of which 26 cases were symptomatic recurrence, typical clinical symptoms were abdominal pain, abnormal defecation and body mass reduction. The survival rate of asymptomatic recurrence patients was higher than that of symptomatic recurrence patients. Conclusion 42% of the recurrent patients were found to rely mainly on the typical clinical symptoms during the random interval follow-up. The primary care doctors should strengthen the monitoring of the typical recurrence symptoms of the patients with higher recurrence rate of colon cancer.
【分类号】：R735.35

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