皮肤炎症启动过程中树突状细胞的迁移及其诱导初始T细胞特异性增殖的数值模拟

发布时间：2018-01-04 18:29

本文关键词：皮肤炎症启动过程中树突状细胞的迁移及其诱导初始T细胞特异性增殖的数值模拟　出处：《生物医学工程学杂志》2017年05期 　论文类型：期刊论文

【摘要】：树突状细胞(DCs)是目前已知的功能最为强大的专职抗原提呈细胞(APCs),在启动和放大固有免疫以及适应性免疫应答中起到重要的作用。在其发挥免疫功能的过程中,DCs的迁移能力以及DCs活化初始T细胞的能力与其发挥免疫功能的效率有着密切关系。然而,由于免疫系统的复杂性,对于皮肤炎症引起DCs免疫应答的过程中细胞数量的动态变化依然知之甚少。因此,本研究利用数学模型对该过程进行数值模拟以及动态预测。通过设置函数和参数初始条件并构建常微分方程,模拟炎症引起免疫应答的初始阶段。结果显示,该方程能够较好地模拟DCs的迁移以及诱导初始T细胞特异性增殖的免疫应答过程,符合实际情况下免疫应答的持续时间、DCs和T细胞的增殖率和迁移率等生理学特性,并且能够对不同时间点DCs与T细胞的数量进行预测,可为研究DCs的免疫学功能提供理论参考,进一步为临床治疗免疫相关疾病提供实践指导。
[Abstract]:Dendritic cells (DCs) is now known as the most powerful professional antigen presenting cells (APCs), at the start and play an important role in innate immunity and adaptive immune response amplification. In the process of the immune function, the efficiency of the migration ability of DCs and DCs activation of naive T cells and play the immune function has a close relationship. However, due to the complexity of the immune system, the skin inflammation caused by changes in the number of DCs cells in immune responses is still poorly understood. Therefore, the study of numerical simulation and dynamic prediction of the process by mathematical model. By setting the function and parameters of initial conditions and construct differential the simulation equation, initial stage of inflammation caused by immune response. The results showed that the immune equation can simulate the migration of DCs and initial T cell specific proliferation induced by Response duration, accord with the actual situation of the immune response, characteristics of DCs and T cell proliferation rate and migration rate and other physiological, and can be a number of different time points of DCs and T cells, can provide a theoretical reference for the study on immunological function of DCs, and provide further guidance to the practice of clinical treatment of immune related diseases.

【作者单位】：贵州医科大学生物与工程学院;贵州医科大学生物与医学工程重点实验室;
【基金】：国家自然科学基金(31660258,31260227,11162003,31771014,11762006) 中国博士后科学基金(2015M582747XB) 教育部科学技术基金重点项目(210196) 贵州省高层次创新型人才培养计划(黔科合平台人才[2016]5676) 贵州省科技创新人才团队(2015-4021) 贵州省2011协同创新计划(2015-04) 贵州省科技合作项目(LH-2015-7336,LH-2016-7375) 贵州省留学归国人员科研基金(2013-8) 贵州省卫计委科学技术基金(gzwjkj2015-1-030) 贵阳市科学技术基金(筑科合同[20161001]029号)
【分类号】：R392
【正文快照】： 微分方程模型来模拟炎症诱导的特异性免疫应答引言启动的初始阶段。皮肤部位炎症引起免疫应答的树突状细胞(dendritic cells,DCs)是一种特化初始阶段可以分为三个阶段:第一阶段,皮肤炎症的抗原提呈细胞(antigen presenting cells,APCs),部位由于抗原的刺激,DCs从外周组织迁移

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