Ikaros家族成员在造血系统发育过程中的作用与意义

发布时间：2018-01-07 01:32

  本文关键词：Ikaros家族成员在造血系统发育过程中的作用与意义　出处：《中国实验血液学杂志》2017年04期 　论文类型：期刊论文

  更多相关文章： Ikaros家族 造血系统 造血细胞 造血发育

【摘要】：造血细胞在发育过程中受许多转录因子调控,其中Ikaros家族是这些转录因子的重要代表之一。Ikaros转录因子具有特征性的保守结构模序,能够与含关键基因启动子或增强子的DNA特异性短序列结合,调控它们的转录活性。同时,Ikaros转录因子还和其它的相关转录调节子之间相互作用,共同调控造血细胞的发育和分化。从结构上观察Ikaros家族,它们属于锌指结构转录因子,包括Ikaros、Helios、Aiolos、Eos和Pegasus 5个成员,分别由IKZF-1、2、3、4、5基因编码。它们是造血作用的主要调节子,通过单独或共同调控发挥作用,特别对淋巴细胞等造血细胞的发生、发展以及功能的正常发挥中具有重要作用,家族成员功能异常时常与疾病的发生、发展相关。本文综述Ikaros家族近年来取得的研究成果,一方面有助于深入理解这个家族在造血系统中的作用及意义,另一方面也为进一步开展研究工作提供可能的研究方向。
[Abstract]:Hematopoietic cells are regulated by many transcription factors during their development. Ikaros family is one of the important representatives of these transcription factors. Ikaros transcription factors have characteristic conserved structural motifs. Ikaros transcriptional factors interact with other related transcriptional regulators by binding to DNA specific short sequences containing key gene promoters or enhancers to regulate their transcriptional activity. The Ikaros family, which belongs to the zinc finger structural transcription factors, including Ikaroslus Heliosae Aiolos, is a common regulation of the development and differentiation of hematopoietic cells. The five members of Eos and Pegasus are encoded by the gene IKZF-1, IkZF-1, 2, 3, 4, 5, respectively. They are the major regulators of hematopoiesis and play a role by single or co-regulation. Especially, it plays an important role in the occurrence, development and function of hematopoietic cells such as lymphocytes. This article reviews the research achievements of Ikaros family in recent years. On the one hand, it is helpful to understand the role and significance of Ikaros family in hematopoietic system. On the other hand, it also provides the possible research direction for further research work.
【作者单位】： 上海交通大学医学院附属第九人民医院肿瘤科;
【分类号】：R331
【正文快照】： J Exp Hematol 2017;25(4):1227-1231Ikaros家族,是锌指结构转录因子,包括Ikaros、Helios、Aiolos、Eos和Pegasus 5个成员,分别由IKZF1-5基因编码。它们是造血作用的主要调节子,其不仅结合到靶基因上游调控序列,通过调控靶基因的表达展现其调节功能,还可参与机体复杂的基因调，

本文编号：1390419