鞘氨醇-1-磷酸转运体Spns2的研究进展

发布时间：2018-01-09 18:12

本文关键词：鞘氨醇-1-磷酸转运体Spns2的研究进展　出处：《国际药学研究杂志》2016年06期 　论文类型：期刊论文

【摘要】：鞘氨醇-1-磷酸(S1P)是一种鞘脂类信号分子,在细胞增殖、分化和迁移等诸多方面发挥重要的调节作用。S1P在细胞内生成,随后释放到细胞外与靶细胞膜上的S1PR受体结合。S1P的体内来源主要是造血细胞和血管内皮细胞。造血细胞中S1P的释放主要通过ABC转运蛋白家族,而血管内皮细胞中S1P的释放则是通过Spns2。Spns2是首个被发现并确认具有重要生理功能的S1P转运蛋白,属于主要协助转运蛋白超家族。应用Spns2基因敲除小鼠模型研究发现Spns2缺陷小鼠的血浆S1P水平较野生小鼠明显下降,淋巴细胞外迁受到抑制。本文将对Spns2的研究历史、结构特性、作用底物、生理功能,以及Spns2与免疫性疾病和癌症的相关性进行简要介绍,为进一步研究Spns2提供重要参考。
[Abstract]:Sphingosine -1- phosphate (S1P) is a kind of sphingolipid signaling molecules in cell proliferation, differentiation and migration and other aspects play an important role in.S1P formation in cells, and then released into the extracellular S1PR of target cell membrane receptor.S1P in vivo is the main source of hematopoietic cells and endothelial cells of hematopoietic cells. The release of S1P mainly through the ABC transporter family, and vascular endothelial cells S1P released by Spns2.Spns2 is the first to be found and confirmed S1P transporter proteins have important physiological functions, which belongs to the main assist transporters. The application of Spns2 gene knockout mice model showed that the plasma S1P level in Spns2 deficient mice than wild mice decreased significantly, lymphocyte relocation was inhibited. This paper will study the history, the structure of the Spns2 substrate, properties, physiological functions, as well as Spns2 and immunological diseases The correlation of cancer is briefly introduced, which provides an important reference for further study of Spns2.

【作者单位】：中国医学科学院北京协和医学院药物研究所创新药物非临床药物代谢及PK/PD研究北京市重点实验室;
【基金】：国家自然基金青年科学基金项目(81302847)
【分类号】：R363
【正文快照】： 鞘氨醇-1-磷酸(sphingosine-1-phosphate,S1P)是属于溶血磷脂(lysophospholipid,LP)的一种两性生物信号分子,结合5种亚型的G蛋白偶联受体(S1PR1-5)调节多种生理功能,如免疫调节、血管发育和再生、炎症诱导及肿瘤发生等,对疾病的发生发展和健康维护都有着重要的作用。S1P在细胞

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