2009～2015年中国山西省发热伴出疹症候群病毒性病原谱流行特征

发布时间：2018-02-24 10:47

本文关键词： 发热伴出疹症候群病毒性病原谱流行病学　出处：《病毒学报》2017年02期 　论文类型：期刊论文

【摘要】：本研究通过对中国山西省2009~2015年哨点医院所采集的发热伴出疹症候群(Rash and fever syndrome,RFS)监测病例中六种病毒性病原体(麻疹病毒,风疹病毒,肠道病毒,水痘-带状疱疹病毒,人类小DNA病毒B19和登革病毒)进行描述性流行病学研究,阐明RFS在人群和时间的分布特点,揭示山西省2009~2015年RFS六种病毒病原谱构成及其流行规律,为山西省进一步开展RFS的预防和控制工作提供科学依据。在2009年1月1日至2015年12月31日期间,山西省共检测RFS监测病例846例,检出RFS病毒性病原阳性病例504例,阳性率为59.57%。其中麻疹病毒阳性192例(38.10%),肠道病毒阳性93例(18.45%),风疹病毒阳性87例(17.26%),水痘-带状疱疹病毒阳性83例(16.47%),人类小DNA病毒B19阳性48例(9.52%),登革病毒阳性1例(0.20%)。RFS阳性病例主要集中在15岁以下的儿童和学生,不同性别之间病原检出率无统计学差异,但不同年龄组的病原谱构成略有差异。RFS发病呈现出明显的季节性,3~8月为其发病高峰。监测数据提示我国应加强RFS系统性和连续性监测,将15岁以下的儿童和青少年作为重点监测人群,不同省份和地市可根据实际发病情况制定出具体的、有针对性的监测方案,以阐明本省或本地区RFS病毒病原的构成及其流行规律和疾病负担。
[Abstract]:In this study, six viral pathogens (measles virus, rubella virus, enterovirus, varicella zoster virus) were collected from Sentinel Hospital of Shanxi Province from 2009 to 2015. A descriptive epidemiological study of human small DNA virus B19 and dengue virus was carried out to elucidate the distribution characteristics of RFS in population and time, and to reveal the composition and epidemic pattern of six kinds of RFS viruses from 2009 to 2015 in Shanxi Province. From January 1st 2009 to December 31st 2015, a total of 846 RFS surveillance cases were detected in Shanxi Province, and 504 positive cases of RFS virus pathogen were detected in Shanxi Province. The positive rate was 59.57.The positive rate of measles virus was 38.1010 in 192 cases, intestinal virus was 18.45, rubella virus was positive in 87 cases, varicella-zoster virus was positive in 83 cases, human small DNA virus B19 positive in 48 cases, dengue virus positive in 1 case. Sexual cases are concentrated in children and students under the age of 15, There was no statistical difference in the detection rate of pathogens among different genders, but there was a slight difference in the composition of pathogeny spectrum among different age groups. The incidence of RFS showed obvious seasonal peak from 3 to August. The monitoring data suggested that the systematic and continuous monitoring of RFS should be strengthened in China. With children and adolescents under the age of 15 as the focus groups, specific and targeted surveillance programmes can be developed in different provinces and municipalities according to the actual incidence of the disease. In order to elucidate the constitution, epidemic regularity and disease burden of RFS virus in our province or region.
【作者单位】：中国疾病预防控制中心病毒病预防控制所卫生部医学病毒与病毒病重点实验室;山西省疾病预防控制中心;
【基金】：“十一五”和“十二五”国家科技重大专项(项目号:2009ZX10004201,2009ZX10004202,2012ZX10004201,2013ZX10004202),题目:“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项传染病监测技术平台项目
【分类号】：R373

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