胎盘生长因子在临床疾病相关作用的研究进展

发布时间：2018-02-26 23:07

本文关键词： 胎盘生长因子子痫前期肿瘤心血管疾病血管生成　出处：《心肺血管病杂志》2016年11期 　论文类型：期刊论文

【摘要】：正胎盘生长因子(placenta growth factor,PLGF)属于血管内皮生长因子家族一种[1],主要存在于胎盘、心脏和肺脏。近年来其一直成为多学科研究热点,在促进血管生成,调节滋养细胞功能,加快缺血疾病进程及促进肿瘤生长等方面的发病机制提供新的思路。本文就PLGF在临床疾病相关作用研究以予综述。1.胎盘生长因子的理化特性PLGF属于血管内皮生长因子(vascular endothelial growth factor,VEGF)家族一种,PLGF为一种分泌型同型二聚体糖蛋白,相对分子质量为29×103,最初于1991年在人类的胎盘cD NA中发现[1],人类的PLGF基因位于14q24-q31,由于
[Abstract]:Positive placenta growth factorial growth factor (PLGF) belongs to the vascular endothelial growth factor family [1], which mainly exists in the placenta, heart and lung. In recent years, it has been a multi-disciplinary research hotspot in promoting angiogenesis and regulating the function of trophoblastic cells. Accelerating the progression of ischemic disease and promoting tumor growth provide new ideas. This article reviews the role of PLGF in clinical diseases. 1.Physicochemical properties of placental growth factor PLGF belong to vascular endothelial growth. Vascular endothelial growth factor (VEGF) family is a secretory homodimer glycoprotein. The relative molecular weight is 29 脳 103. It was first found in human placenta cdna in 1991. The human PLGF gene is located at 14q24-q31.
【作者单位】：首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所妇产科;
【分类号】：R363

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