中性粒细胞胞外诱捕网和血栓形成的研究进展

发布时间：2018-03-07 03:09

本文选题：中性粒细胞胞外诱捕网　切入点：炎症　出处：《现代生物医学进展》2016年03期 　论文类型：期刊论文

【摘要】：中性粒细胞胞外诱捕网是由DNA骨架、组蛋白、颗粒成分以及胞浆蛋白组成的网状物,它通过捕获致病微生物,抑制其扩散、灭活毒力因子以及清除病原体来发挥抗菌活性,中性粒细胞这种与其经典的趋化、吞噬作用不同的胞外杀菌方式发挥着重要的固有免疫应答作用。然而,中性粒细胞胞外诱捕网的产生是一把双刃剑。近年来有研究表明它可以导致凝血异常、刺激血栓形成并为其提供支架,但这一过程的机制并不十分清楚,可能与中性粒细胞胞外诱捕网的促凝活性以及凝血级联反应的激活有关。本文将就中性粒细胞胞外诱捕网及其与血栓形成之间关系的研究进展做一综述。
[Abstract]:The neutrophil extracellular entrapment is a network of DNA skeletons, histone, granule components and cytoplasmic proteins that act as antimicrobial agents by capturing pathogenic microorganisms, inhibiting their diffusion, inactivating virulence factors, and scavenging pathogens. Neutrophilic granulocyte, which is different from its classical chemotaxis and phagocytosis, plays an important role in innate immune response. The production of neutrophil extracellular trapping nets is a double-edged sword. Recent studies have shown that it can lead to abnormal coagulation, stimulate thrombosis and provide stents, but the mechanism of this process is not very clear. It may be related to the procoagulant activity of neutrophil extracellular trapping net and the activation of coagulation cascade reaction. This article reviews the research progress of neutrophil extracellular trapping net and its relationship with thrombosis.
【作者单位】：哈尔滨医科大学附属第一医院;
【基金】：国家自然科学基金项目(81270588)
【分类号】：R363

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