小窝蛋白-1在免疫调节中的作用

发布时间：2018-04-12 18:54

本文选题：小窝 + 小窝蛋白-　；参考：《中国生物化学与分子生物学报》2016年03期

【摘要】：小窝(caveolae)是一类特殊的膜脂筏,富含鞘磷脂和胆固醇。小窝蛋白-1(caveolin-1)是小窝的标志蛋白质,分子量约22 k D。后者不但直接参与小窝结构的形成、膜泡运输、胆固醇稳态维持,还通过其脚手架结构域(caveolin scaffolding domain,CSD)与众多信号分子相互作用调控细胞的生长、发育和分化,最终影响机体的生理和病理过程。近年发现,小窝蛋白-1和胞膜窖不但存在于内皮细胞、脂肪细胞、血管平滑肌细胞和纤维细胞中,还广泛表达于免疫细胞中,参与调节免疫细胞活化引起的炎症应答反应。本文结合最新的研究进展和前期结果,简要综述小窝蛋白-1在巨噬细胞、T细胞、B细胞以及中性粒细胞等免疫细胞内的调节作用,以及在细菌感染如绿脓杆菌、沙门氏菌和克雷伯杆菌的炎症中的信号转导研究进展。
[Abstract]:Caveolae) is a special membrane lipid raft rich in sphingolipid and cholesterol.Fossa protein-1 (caveolin-1) is the marker protein of the litter, and its molecular weight is about 22 KD.The latter is not only directly involved in the formation of fossa structure, membrane vesicle transport and cholesterol homeostasis, but also regulates the growth, development and differentiation of cells through the interaction of caveolin scaffolding domain with many signaling molecules.Ultimately affect the body's physiological and pathological processes.In recent years, it has been found that fossa protein 1 and cell membrane cellar not only exist in endothelial cells, adipocytes, vascular smooth muscle cells and fibroblasts, but also are widely expressed in immune cells, which are involved in regulating the inflammatory response induced by the activation of immune cells.In this paper, the regulation of fossa protein 1 in T cell B cells, neutrophils and other immune cells of macrophages and bacterial infections such as Pseudomonas aeruginosa were reviewed.Advances in signal transduction in inflammation of Salmonella and Klebsiella.
【作者单位】：辽宁师范大学生命科学学院;解放军第210医院;
【基金】：国家自然科学基金(No.30570225;No.30970353)资助~~
【分类号】：R392

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