血管支架物理力学性能实验研究

发布时间：2018-05-12 11:02

本文选题：血管支架 + 物理力学性能　；参考：《山东大学》2011年硕士论文

【摘要】：近年来随着血管支架用量的逐年增加,人们越来越关注其在使用过程中的安全性和有效性问题,物理力学性能是保证使用有效性以及决定临床使用效果的关键因素。但目前物理力学性能指标的检测以各个厂家的自定标准为主,实验方法的差异造成了产品间对比的困难性,因此在统一实验方法的基础上对支架的性能进行研究具有重要的理论价值。本文以血管支架的物理力学性能为研究对象,在相同实验条件下对血管支架进行实验研究和性能比对研究：通过对血管支架的物理力学性能指标进行综合分析,选择支架的径向力学性能和耐疲劳性能进行研究,分析得出关键性的影响因素,为后续实验研究建立理论基础。平行选择了相同适应症、相同公称内径的球囊扩张式支架,以及不同用途的自膨式支架作为研究对象,进行了径向力学性能的实验研究,研究结果表明：统一的实验方法有利于血管支架间性能的比较,但对血管支架优劣的比较,则应考虑各个因素的综合影响；实际血管支架间的个体差异性和复杂性,决定了对支架成品进行实验研究的必要性并应建立相应的评价体系。对血管支架耐疲劳性能实验的关键参数进行了测试分析,并对疲劳实验后血管支架的径向力学性能进行实验研究,简化了疲劳实验过程中参数测试的步骤,结论表明疲劳实验显著降低了血管支架的径向力学性能,提出应建立疲劳实验后的评价体系。本课题的研究将相同产品、相同实验条件的观念引入目前的检测理念,弥补了目前实际产品检测数据的空白,并首次在相同冠脉支架间进行了横向对比,提出了血管支架评价方法的解决方案,为建立血管支架产品检测评价体系奠定了基础。
[Abstract]:In recent years, with the increasing use of vascular stents, more and more attention has been paid to the safety and effectiveness of vascular stents. Physical and mechanical properties are the key factors to ensure the effectiveness and determine the clinical efficacy. But at present, the test of physical and mechanical properties is mainly based on the self-set standards of each manufacturer. The differences in experimental methods make it difficult to compare products. Therefore, it is of great theoretical value to study the performance of scaffolds on the basis of unified experimental methods. In this paper, the physical and mechanical properties of vascular stents are studied. Under the same experimental conditions, the experimental study and performance ratio study of vascular stents are carried out. Through the comprehensive analysis of the physical and mechanical properties of the vascular stent, the radial mechanical properties and fatigue resistance of the stent were studied, and the key influencing factors were obtained, which established the theoretical foundation for the subsequent experimental study. The radial mechanical properties of the balloon dilated stent with the same indication, the same nominal inner diameter, and the self-expanding stent with different uses were studied in parallel. The results show that the unified experimental method is beneficial to the comparison of the performance of vascular stents, but the comprehensive effects of various factors should be taken into account in comparing the advantages and disadvantages of vascular stents, and the individual differences and complexity among the actual vascular stents, The necessity of experimental study on the finished scaffold is determined and the corresponding evaluation system should be established. The key parameters of the fatigue resistance test of vascular stent are tested and analyzed, and the radial mechanical properties of the vascular stent after fatigue test are studied, which simplifies the steps of parameter testing in the fatigue experiment. The results show that fatigue test can significantly reduce the radial mechanical properties of vascular stent, and the evaluation system should be established after fatigue test. In this paper, the concept of the same product and the same experimental condition is introduced into the present testing idea, which makes up the blank of the actual product test data, and makes the horizontal contrast between the same coronary stent for the first time. The solution of vascular stent evaluation method was put forward, which laid a foundation for the establishment of vascular stent product evaluation system.
【学位授予单位】：山东大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R312

【引证文献】