清化颗粒对高脂饲料诱导肥胖模型大鼠的减重效应及血清瘦素的影响

发布时间：2018-05-25 01:28

本文选题：清化颗粒 + 肥胖　；参考：《中华中医药杂志》2016年03期

【摘要】：目的:探讨清化颗粒的减重效应及对血清瘦素的影响。方法:建立高脂饲料诱导的肥胖大鼠模型,随机分为模型对照组、清化颗粒组、奥利司他组,另设正常对照组(普通饲料饲养),连续灌胃给药4周,观察各组大鼠体质量、体脂肪量、进食量、脂肪细胞形态及血清瘦素变化。结果:干预4周后,清化颗粒组体质量及体脂肪量均低于模型对照组(P0.01),与奥利司他组差异不明显。清化颗粒组进食量下降,其它各组大鼠进食量呈上升趋势(P0.01)。各组肥胖大鼠血清瘦素浓度均高于正常对照组(P0.01),清化颗粒组大鼠血清瘦素浓度低于模型对照组(P0.05)。与模型对照组相比,清化颗粒组和奥利司他组大鼠肾周及附睾脂肪细胞面积减小,细胞数目增多。结论:清化颗粒可以降低肥胖大鼠的体质量和体脂肪量及血清瘦素水平。
[Abstract]:Objective: to study the weight loss effect of Qinghua granule and its effect on serum leptin. Methods: the obese rats induced by high fat diet were randomly divided into three groups: model control group, Qinghua granule group, orlistat group, and normal control group (fed with normal diet for 4 weeks). The body weight of rats in each group was observed. Changes in body fat, food intake, adipocyte morphology and serum leptin levels. Results: after 4 weeks of intervention, the body weight and body fat content of Qinghua granule group were lower than that of model control group (P 0.01), and there was no significant difference between Qinghua granule group and olinastar group. The intake of Qinghua granule group decreased, while that of other groups showed an increasing trend (P 0.01). The serum leptin concentration of the obese rats in each group was higher than that of the normal control group (P 0.01), and the serum leptin concentration in the Qinghua granule group was lower than that in the model control group (P 0.05). Compared with the model control group, the area of perirenal adipocytes and epididymal adipocytes decreased and the number of cells increased in Qinghua granule group and orlistat group. Conclusion: Qinghua granule can reduce the body weight, body fat and serum leptin level of obese rats.
【作者单位】：上海中医药大学附属曙光医院;上海市科委中医临床重点实验室;上海中医药大学;
【基金】：国家自然科学基金青年基金项目(No.8140335924) 上海市自然科学基金项目(No.13ZR1442700;No.15ZR1442100) 上海市浦东新区中医药事业发展基金项目(No.PDYNZJ2015-23)~~
【分类号】：R285.5;R-332

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