小鼠B细胞亚群增龄变化的研究进展

发布时间：2018-06-07 12:56

本文选题：B细胞 + B细胞亚群　；参考：《细胞与分子免疫学杂志》2017年06期

【摘要】：机体的免疫包括固有免疫和适应性免疫,适应性免疫占据很重要的地位,主要有B和T细胞参与,其中B细胞在适应性免疫中发挥重要的作用。随着对B细胞研究的深入,发现不同月龄的小鼠中,B细胞数量、亚群及功能随月龄的改变表现出特征性的动态变化,这些动态变化主要通过细胞和分子水平导致B细胞分化受损,影响机体的免疫功能。小鼠B细胞亚群在衰老过程中的变化,为特异性免疫应答功能的进展等研究提供了基础,也为人类疾病治疗与预防发挥着越来越重要的作用。
[Abstract]:The immunity of organism includes innate immunity and adaptive immunity. Adaptive immunity plays an important role in adaptive immunity, mainly involving B and T cells. With the further study of B cells, it was found that the number, subsets and function of B cells in mice of different months of age showed a characteristic dynamic change with the change of age. These dynamic changes mainly result in the damage of B cell differentiation through cell and molecular level, and affect the immune function of the body. The changes of mouse B cell subsets during aging provide a basis for the development of specific immune response and play a more and more important role in the treatment and prevention of human diseases.
【作者单位】：遵义医学院免疫学教研室贵州省免疫学研究生教育创新基地;
【基金】：国家自然科学基金(81660269) 教育部新世纪优秀人才支持计划(NCET-10-0095)
【分类号】：R392

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