芦荟复方制剂对糖尿病模型小鼠的降糖作用研究

发布时间：2018-06-09 17:42

本文选题：库拉索芦荟 + 苦瓜　；参考：《现代预防医学》2017年01期

【摘要】：目的研究库拉索芦荟、苦瓜、葛根复方制剂对糖尿病模型小鼠血糖和糖耐量影响。方法实验一为正常小鼠,设空白对照和芦荟复方制剂高剂量组0.6 g/(kg·BW);实验二采用四氧嘧啶诱发小鼠糖尿病模型,造模成功后随机分为模型对照组和芦荟复方制剂低0.15 g/(kg·BW)、中0.3 g/(kg·BW)、高0.6 g/(kg·BW)剂量组。灌胃相应剂量的芦荟复方制剂或蒸馏水30天后,测定正常小鼠空腹血糖以及糖尿病模型小鼠空腹血糖和糖耐量的变化。结果芦荟复方制剂不影响正常小鼠的体重和空腹血糖水平。芦荟复方制剂3个剂量组与模型对照组比较,空腹血糖(F=9.2470,P=0.000 1)、0.5 h血糖(F=3.010,P=0.043)、2 h血糖(F=7.496,P=0.001)和血糖曲线下面积(F=6.090,P=0.002)均降低,差异有统计学意义。结论芦荟复方制剂具有降低糖尿病模型小鼠血糖和改善糖耐量的作用。
[Abstract]:Objective to study the effects of compound preparation of aloe vera, Momordica charantia and Pueraria lobata on blood glucose and glucose tolerance in diabetic mice. Methods in experiment 1, normal mice were divided into blank control group and aloe compound preparation group (0. 6 g/(kg BWN), and in experiment 2, alloxan was used to induce diabetes in mice. After the establishment of the model, the rats were randomly divided into two groups: model control group and aloe compound preparation group with low dose of 0.15 g/(kg BWW, medium dose of 0.3 g/(kg BWW and high dose of 0.6 g/(kg BW. The changes of fasting blood glucose and glucose tolerance in normal mice and diabetic model mice were measured after 30 days of oral administration of aloe compound preparation or distilled water. Results Aloe compound preparation did not affect the body weight and fasting blood glucose level of normal mice. Compared with the model control group, the fasting blood glucose (FG) of the three dosage groups of aloe compound preparation was decreased significantly (F0. 010, P0. 010, P0. 043, P0. 043, P0. 001) and the area under the blood glucose curve (F0. 090, P0. 002). Conclusion Aloe compound preparation can reduce blood glucose and improve glucose tolerance in diabetic mice.
【作者单位】：四川大学华西公共卫生学院(华西第四医院)四川省食品安全监测与风险评估重点实验室;
【基金】：功能性食品安全性评价与功能因子关键检验技术(2010-2012):863计划重点项目(项目编号:2010AA023001)
【分类号】：R285.5;R-332

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