胸主动脉模型脉动血流数值模拟
发布时间：2018-07-24 10:32
【摘要】：目的基于逆向工程技术建立正常主动脉和胸主动脉瘤的个体化模型，应用计算流体动力学方法进行脉动血流数值模拟，探讨主动脉夹层的病因机制以及胸主动脉瘤生长、破裂的机制。方法用MIMICS软件读取DICOM格式CTA数据，重建三维主动脉模型，应用有限体积法Fluent软件进行血流数值模拟，分析与胸主动脉夹层形成及动脉瘤生长、破裂相关的血流动力学参数。 结果 （1）正常胸主动脉数值模拟血流动力学参数。 （2）胸主动脉瘤数值模拟血流动力学参数。结论 （1）基于高分辨率CTA数据可以重建解剖精确的三维血管模型，计算机数值模拟是研究胸主动脉血流动力学参数的有效手段。 （2）脉动流条件下，胸主动脉血流流场复杂，，胸主动脉几何形态对血流方式有较大影响，湍流不利于血液流动。 （3）胸主动脉压力的波动与主动脉夹层的形成有关。 （4）低壁切应力与胸主动脉粥样硬化及斑块形成有关。 （5）低壁切应力与胸主动脉瘤的生长、破裂有关。 （6）低壁切应力与胸主动脉瘤体内附壁血栓形成有关。
[Abstract]:Objective to establish individual models of normal and thoracic aortic aneurysms based on reverse engineering, and to investigate the etiological mechanism of aortic dissection and the growth of thoracic aortic aneurysms by using computational fluid dynamics (CFD). The mechanism of rupture. Methods MIMICS software was used to read the CTA data of DICOM format, and 3D aortic model was reconstructed. The hemodynamic parameters related to the formation of thoracic aortic dissection, the growth and rupture of aneurysms were analyzed by using the finite volume method Fluent software. Results (1) normal thoracic aorta were numerically simulated with hemodynamic parameters, (2) thoracic aortic aneurysms were numerically simulated with hemodynamic parameters. Conclusion (1) Three-dimensional vascular model can be reconstructed by high-resolution CTA data. Computer numerical simulation is an effective method to study the hemodynamic parameters of thoracic aorta. (2) under pulsating flow conditions, The flow field of thoracic aorta is complex and the geometry of thoracic aorta has great influence on the blood flow pattern. (3) the fluctuation of thoracic aortic pressure is related to the formation of aortic dissection. (4) low wall shear stress is related to the formation of atherosclerosis and plaque in thoracic aorta. Shear stress and the growth of thoracic aortic aneurysms, (6) low wall shear stress is associated with mural thrombosis in thoracic aortic aneurysms.
【学位授予单位】：中国人民解放军医学院
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R331
本文编号：2141094
[Abstract]:Objective to establish individual models of normal and thoracic aortic aneurysms based on reverse engineering, and to investigate the etiological mechanism of aortic dissection and the growth of thoracic aortic aneurysms by using computational fluid dynamics (CFD). The mechanism of rupture. Methods MIMICS software was used to read the CTA data of DICOM format, and 3D aortic model was reconstructed. The hemodynamic parameters related to the formation of thoracic aortic dissection, the growth and rupture of aneurysms were analyzed by using the finite volume method Fluent software. Results (1) normal thoracic aorta were numerically simulated with hemodynamic parameters, (2) thoracic aortic aneurysms were numerically simulated with hemodynamic parameters. Conclusion (1) Three-dimensional vascular model can be reconstructed by high-resolution CTA data. Computer numerical simulation is an effective method to study the hemodynamic parameters of thoracic aorta. (2) under pulsating flow conditions, The flow field of thoracic aorta is complex and the geometry of thoracic aorta has great influence on the blood flow pattern. (3) the fluctuation of thoracic aortic pressure is related to the formation of aortic dissection. (4) low wall shear stress is related to the formation of atherosclerosis and plaque in thoracic aorta. Shear stress and the growth of thoracic aortic aneurysms, (6) low wall shear stress is associated with mural thrombosis in thoracic aortic aneurysms.
【学位授予单位】：中国人民解放军医学院
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R331
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本文编号：2141094
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