小型猪与大鼠不同记录部位诱发VEMP的比较

发布时间：2018-08-19 13:58

【摘要】：目的分析正常小型猪不同记录部位(颈部伸肌、咬肌)的前庭诱发肌源性电位(vestibular evoked myogenic potential,VEMP)波形图,并与大鼠的VEMP波形图进行比较;方法各选取12只前庭功能正常的大鼠和小型猪,进行麻醉之后,用自制装置进行固定,1000Hz强短声诱发颈部伸肌、咬肌肌源性电位,并记录其波形;结果大鼠颈部伸肌诱发的肌源性电位,第一个正向波P的潜伏期为6.45±0.23ms,振幅约1.45±0.49uv,80dB SPL引出率为58%;咬肌诱发肌源性电位,第一个正向波P的潜伏期为6.38±0.34ms,振幅约1.57±0.35uv,阈值80dB SPL引出率为50%。小型猪颈部伸肌诱发肌源性电位,第一个正向波P的潜伏期7.65±0.64ms,振幅1.66±0.34uv,80dBSPL的引出率为58%;咬肌诱发肌源性电位,第一个正向波P的潜伏期7.60±0.78ms,振幅1.31±0.28uv,80dBSPL的引出率为50%。结论小型猪和大鼠不同部位记录得到的VEMP,只有振幅和引出率的差异,而潜伏期没有统计学意义;从波形的重复性、波幅的大小、引出率以及潜伏期的综合考虑,小型猪咬肌部位记录的VEMP波形优于颈部伸肌,大鼠颈部伸肌记录得到的VEMP波形优于咬肌;在相同部位记录到VEMP第一个正向P波的潜伏期时间、波幅的大小方面小型猪较大鼠的稍高。
[Abstract]:Objective to analyze the vestibular evoked myogenic potential (vestibular evoked myogenic potentialVEMP (VEP) waveforms of normal miniature pigs at different recording sites (extensor cervicalis, masseter muscle) and compare them with VEMP waveforms of rats. Methods Twelve normal vestibular function rats and mini-pigs were selected respectively. After anesthesia, the cervical extensor muscle and masseter muscle myogenic potential were induced with a fixed device of 1000Hz strong short sound, and its waveform was recorded. Results the myogenic potential induced by the cervical extensor muscle in rats, The latency of the first forward wave P was 6.45 卤0.23msand the amplitude was about 1.45 卤0.49uvn 80dB SPL. The myogenic potential evoked by masseter muscle was 6.38 卤0.34ms, the amplitude was about 1.57 卤0.35uv, and the threshold 80dB SPL extraction rate was 50. The first forward wave P was 7.65 卤0.64 msand the extraction rate of the first forward wave P was 1.66 卤0.34 uvn 80dBSPL, and that of masseter muscle evoked myogenic potential was 7.60 卤0.78msof the first forward wave P, and the extraction rate of the first forward wave P was 1.31 卤0.28uvlvlb SPL was 50dB. Conclusion the VEMPs recorded in different parts of miniature pigs and rats have only the difference of amplitude and extraction rate, but there is no significant difference in latent period, considering the repeatability of waveform, magnitude of wave amplitude, extraction rate and incubation period. The VEMP waveform recorded in the masseter muscle of miniature pig was better than that in the extensor muscle of neck, the VEMP waveform recorded by the extensor muscle of rat neck was superior to that of the masseter muscle, and the latency time of the first positive P wave of VEMP was recorded in the same position. The amplitudes were slightly higher in the larger miniature pigs.
【作者单位】：徐州医学院听力中心;中国人民解放军总医院耳鼻咽喉头颈外科;重庆市畜牧科学院;徐州医学院附属医院临床听力中心;
【基金】：国家973计划重大科学研究计划干细胞项目(2012CB967900),国家973计划重大科学问题导向项目(2011CBA01000) 国家自然科学基金青年项目(81400472) 重庆市基本科研业务费项目(11611;14440) 江苏省六大人才高峰2014-WSN-043 中国博士后基金2015M571818 江苏省高等学校大生创新创业训练计划201510313003Z~~
【分类号】：R339.16

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