昼夜节律产生和维持的调控系统

发布时间：2018-08-19 14:24

【摘要】：昼夜节律是在一系列生物钟基因(bmal1、clock、cry、per)和钟控基因(rev-erbα、rorα、dbp、tef、hlf等)的转录和翻译调控环路、翻译后修饰和降解机制的周期性驱动下,机体的生理、生化、行为等生命活动表现为以大致24 h为周期的振荡规律现象。昼夜节律产生和维持的调控系统由中枢和外周生物钟系统、节律输入系统和节律输出系统组成。节律输入系统感受并向中枢生物钟系统传递以光信号为代表的环境同步信号,中枢生物钟系统作为昼夜节律主起搏器通过输出系统将产生的节律信号传递至外周,并与外周器官内源性生物钟系统协同作用维持机体的生理活动。光照、温度、进食时间、营养物质、代谢相关因子等多种内源和外源性调控因子可作用于生物钟网络并在昼夜节律稳态维持中发挥重要作用。该文将着重阐述昼夜节律产生和维持的生理基础及相关调控因子。
[Abstract]:The circadian rhythm is the circadian loop of transcription and translation regulation of a series of biological clock genes (bmal1 clock cryper) and clock controlled genes (rev-erb 伪 error 伪), which are driven by the periodic mechanism of post-translational modification and degradation. Behavior and other life activities are oscillatory phenomena with a period of about 24 hours. The regulation system of circadian rhythm generation and maintenance consists of central and peripheral biological clock system, rhythm input system and rhythm output system. The rhythmic input system senses and transmits the environmental synchronization signals represented by light signals to the central biological clock system. The central circadian clock system acts as a circadian rhythm master pacemaker to transmit the produced rhythmic signals to the periphery through the output system. And with the peripheral organs of endogenous biological clock system to maintain the physiological activities of the body. Many endogenous and exogenous regulatory factors, such as light, temperature, feeding time, nutrients, metabolism-related factors, can act on the circadian clock network and play an important role in the homeostasis of circadian rhythm. This paper will focus on the physiological basis of circadian rhythm production and maintenance and related regulatory factors.
【作者单位】：军事医学科学院基础医学研究所军事应激医学研究室;
【基金】：全军医学科研“十二五”重大资助项目(AWS14J011) 北京市自然科学基金青年资助项目(7164287) 细胞应激生物学国家重点实验室(厦门大学)开放基金资助项目(SKLCSB2016KF010)
【分类号】：R33

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