缺氧诱导因子Hif-1在慢性感染中作用机制的研究进展
发布时间：2018-10-22 15:48
【摘要】：正缺氧诱导因子1(hypoxia induced factor 1,Hif-1)是介导细胞对缺氧微环境进行适应性反应的关键转录调控因子,在血管新生、能量代谢、细胞增殖、免疫应答、组织纤维化和修复等方面起重要作用。Hif-1是1992年Semenza等~([1])在低氧处理肝癌细胞株Hep3B时发现的,第一个被证实的靶基因是人促红细胞生成素(human erythropoietin,EPO),在细胞适应低氧环境和肿瘤发展的过程中,Hif-1扮
[Abstract]:Positive hypoxia inducible factor 1 (hypoxia induced factor 1 (Hif-1) is a key transcriptional regulator for the adaptive response of cells to anoxic microenvironment. It plays an important role in angiogenesis, energy metabolism, cell proliferation and immune response. Tissue fibrosis and repair play an important role. Hif-1 was discovered by Semenza et al. (1) in 1992 when Hep3B cells were treated with hypoxia. The first confirmed target gene is human erythropoietin (human erythropoietin,EPO), which Hif-1 plays during cell adaptation to hypoxia and tumor development.
【作者单位】： 华中科技大学同济医学院基础医学院病原生物学系;华中科技大学同济医学院附属协和医院康复科;
【基金】：国家自然科学基金资助项目(No.81470855) 华中科技大学大学生创新创业训练计划资助项目(No.2016-0118540283) 湖北省自然科学基金青年项目(No.2015CFB376)
【分类号】：R364.4
，
本文编号：2287596
[Abstract]:Positive hypoxia inducible factor 1 (hypoxia induced factor 1 (Hif-1) is a key transcriptional regulator for the adaptive response of cells to anoxic microenvironment. It plays an important role in angiogenesis, energy metabolism, cell proliferation and immune response. Tissue fibrosis and repair play an important role. Hif-1 was discovered by Semenza et al. (1) in 1992 when Hep3B cells were treated with hypoxia. The first confirmed target gene is human erythropoietin (human erythropoietin,EPO), which Hif-1 plays during cell adaptation to hypoxia and tumor development.
【作者单位】： 华中科技大学同济医学院基础医学院病原生物学系;华中科技大学同济医学院附属协和医院康复科;
【基金】：国家自然科学基金资助项目(No.81470855) 华中科技大学大学生创新创业训练计划资助项目(No.2016-0118540283) 湖北省自然科学基金青年项目(No.2015CFB376)
【分类号】：R364.4
，
本文编号：2287596
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