丹参水提物对小鼠病理脱发模型毛发的再生影响

发布时间：2018-11-20 17:33

【摘要】：目的研究丹参水提物对小鼠病理脱发模型毛发再生的促进作用.方法睾酮诱导建立小鼠脱发模型,分为空白组,模型组,章光101组,丹参低、中、高剂量组(20、40、80 mg/m L)组.涂药21 d,测量脱毛区毛长、毛重和毛囊数,检测血清睾酮(T)、雌二醇(E2)含量,脱毛区皮肤组织血管内皮生长因子(VEGF)、丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)含量.结果 (1)丹参水提物能明显促进小鼠再生毛发的毛长、毛重和毛囊数(P0.05);(2)降低T和提高E2含量(P0.05),平衡激素水平;(3)提高SOD和GSH-Px活性,降低MDA含量(P0.05);(4)提高VEGF含量(P0.05).结论在睾酮诱导的小鼠病理脱发模型中,丹参水提物能有效促进毛发的再生,其作用机制可能与平衡激素水平、抗氧化和促进VEGF表达有关.
[Abstract]:Objective to study the effect of salvia miltiorrhiza extract on hair regeneration in mice with pathological alopecia. Methods the model of alopecia induced by testosterone in mice was divided into blank group, model group, Zhangguang 101 group, salvia miltiorrhiza low, middle and high dose group (200.4080 mg/m / L). The hair length, wool weight and hair follicle number were measured at 21 days. Serum testosterone (T), estradiol (E2) and vascular endothelial growth factor (VEGF),) (VEGF), malondialdehyde (MDA), superoxide dismutase (SOD),) were measured. Glutathione peroxidase (GSH-Px) content. Results (1) the water extract of Salvia miltiorrhiza could significantly promote the hair length, hair weight and hair follicle number (P0.05); (2), decrease T and increase E2 content (P0.05), and balance the hormone level. (3) increase the activity of SOD and GSH-Px, decrease the content of MDA (P0.05); (4) and increase the content of VEGF (P0.05). Conclusion the aqueous extract of Salvia miltiorrhiza can effectively promote hair regeneration in mice induced by testosterone, and its mechanism may be related to the balance of hormone level, antioxidation and VEGF expression.
【作者单位】：昆明医科大学生物医学工程研究中心;昆明医科大学第三附属医院;滇西应用技术大学;
【基金】：云南省自然科学基金资助项目(2014FB060) 云南省教育厅科研基金重点项目(2013Z112)
【分类号】：R285.5;R-332

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