抗体依赖增强效应发生机制研究进展

发布时间：2019-04-19 06:36

【摘要】：在各类病原体特别是病毒的感染中,抗体依赖增强效应(Antibody-dependent enhancement,ADE)可使原有的感染加重,引起严重疾病。研究发现多种病原体的感染过程中均有抗体依赖增强效应ADE现象,且可能存在不同的发生机制。随着抗体依赖增强效应ADE现象产生机制研究的不断深入,有助于相应病原体疫苗的改造,从而使疫苗效用最大化,对控制包括寨卡病毒在内的病原体的感染将提供巨大帮助。本文就近年来抗体依赖增强效应ADE发生机制的研究进展进行综述,包括Fc段受体依赖、补体系统介导、非中和抗体介导、病毒表面蛋白介导及细胞活动介导的抗体依赖增强效应ADE机制,同时以登革病毒、人类免疫缺陷病毒、柯萨奇病毒、埃博拉病毒、寨卡病毒及其他病原体为例进行分类介绍。
[Abstract]:Antibody dependent enhancement effect (Antibody-dependent enhancement,ADE) can aggravate the original infection and cause serious diseases in the infection of all kinds of pathogens, especially the virus. It was found that antibody-dependent enhancement effect (ADE) was found in the infection process of various pathogens, and there might be different mechanisms of infection. With the deepening of the study on the mechanism of antibody-dependent enhancement effect ADE phenomenon, it is helpful to reform the corresponding pathogen vaccine, thus maximizing the efficacy of the vaccine, and will provide great help to control the infection of pathogens, including Zika virus. This review reviews the recent advances in the mechanism of antibody-dependent enhancement of ADE, including Fc segment receptor dependence, complement system-mediated, and non-neutralizing antibody-mediated. The ADE mechanism of antibody-dependent enhancement mediated by viral surface protein and cell activity is also introduced in this paper, including dengue virus, human immunodeficiency virus, Coxsackie virus, Ebola virus, Zika virus and other pathogens.
【作者单位】：南方医科大学公共卫生学院三级生物安全实验室;南方医科大学第一临床医学院;
【基金】：国家自然科学基金(No.31270974,No.31470271) 广东省及广州市防控登革热应急科技攻关项目(No.2013A020229004,No.201508020263)联合资助~~
【分类号】：R392

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