白金颗粒对盆腔炎性疾病后遗症模型大鼠的药效学

发布时间：2019-06-12 04:18

【摘要】：目的研究壮药白金颗粒(白背叶根和金刚刺)对盆腔炎性疾病后遗症模型大鼠的药效学。方法用大肠杆菌和金黄色葡萄球菌的混合菌加机械损伤法建立盆腔炎性疾病后遗症大鼠模型,随机分为模型组,白金颗粒高、中、低剂量组,阳性对照组(地塞米松片、花红颗粒),空白对照组及假手术组8组,每组10只大鼠。连续给药14 d后,于末次给药24 h大鼠腹主动脉取血,检测血液流变学、血常规,观察子宫组织病理形态。结果模型大鼠的血液流变学指标及白细胞数、中性粒细胞百分比显著降低,子宫组织病理形态显著改善。结论白金颗粒对大鼠盆腔炎性疾病后遗症有较好的治疗作用。
[Abstract]:Objective to study the pharmacokinetics of Zhuangyi Baijin granule (white dorsal leaf root and kanggang thorn) on the sequelae of pelvic inflammatory disease in rats. Methods the rat model of sequelae of pelvic inflammatory diseases was established by the method of mixed bacteria of Escherichia coli and Staphylococcus aureus and mechanical injury. The rats were randomly divided into model group, platinum granule high, middle and low dose group, positive control group (dexamethasone tablets, Hua Hong granule), blank control group and false operation group with 10 rats in each group. After 14 days of continuous administration, blood samples were taken from abdominal aorta of rats at 24 h after the last administration, hemorheology and blood routine were measured, and the pathological morphology of uterine tissue was observed. Results the hemorheological indexes, leukocyte count and neutrophil percentage of the model rats were significantly decreased, and the pathological morphology of uterine tissue was significantly improved. Conclusion Baijin granule has a good therapeutic effect on sequelae of pelvic inflammatory diseases in rats.
【作者单位】：广西高校中药制剂共性技术研发重点实验室;广西中医药大学;广西国际壮医医院;
【基金】：广西壮族自治区卫生厅中医药科技专项(GZZJ14-08) 广西自然科学基金项目(2014GXNSFAA118182) 广西高校科技创新能力提升工程专项项目(70-ZJGX201501001)
【分类号】：R285.5;R-332

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