Shenfu Injection Western medicine septic shock effect safety

  本文关键词：参附注射液联合西药治疗感染性休克临床疗效观察，由笔耕文化传播整理发布。

参附注射液联合西药治疗感染性休克临床疗效观察

Clinical Efficacy on Shenfu Injection Combined with Western Medicine Treatment of Septic Shock

[1] [2]

ZHU Li,JIN Ni （ ICU, Central Hospital of Jinhua, Jinhua 321000, Zhejiang, China）

金华市中心医院ICU,浙江金华321000

文章摘要：目的：探讨参附注射液联合西药治疗感染性休克临床疗效观察及其安全性评价。方法：将118例感染性休克患者按照随机分组法分为对照组58例和观察组60例。对照组给予西药治疗,观察组在对照组基础上结合参附注射液治疗。两组连续用药5 d。对比分析两组用药5 d后临床疗效,治疗前、治疗24 h和48 h血乳酸浓度和血清炎症因子水平变化。结果：观察组总有效率（88.33%）显著高于对照组（68.97%）（P〈0.05）;两组血乳酸浓度治疗前比较无统计学差异（P〉0.05）;两组血乳酸浓度治疗24 h、48 h较治疗前显著降低减少（P〈0.05）;观察组血乳酸浓度治疗24 h和48 h后显著低于对照组（P〈0.05）;两组血清IL-6、TNF-α治疗前比较无统计学差异（P〉0.05）;两组血清IL-6、TNF-α治疗24 h、48 h较治疗前显著降低减少（P〈0.05）;观察组血清IL-6、TNF-α治疗24 h和48 h后显著低于对照组（P〈0.05）;两组治疗期间均未见明显不良反应。结论：参附注射液联合西药治疗感染性休克临床疗效显著,安全可靠,具有重要研究意义。

Abstr：Objective： To investigate the clinical efficacy and safety evaluation of Shenfu Injection combined with Western medicine for septic shock. Methods： 118 cases of patients with septic shock were randomly divided into control group（ n = 58） and observation group（ n = 60）. The control group received Western medicine treatment and observation group combined Shenfu Injection. Two groups were given continuous medication for 5 d. Comparison of the clinical efficacy after5 d,blood lactate concentration and serum levels of inflammatory cytokines before treatment,24 h and 48 h after treatment. Results： The overall response rate（ 88. 33%） of the observation group was significantly higher than that of the control group（ 68. 97%）（ P〉 0. 05）. Before treatment,the two groups＇ blood lactate concentration had no significant difference（ P 〉0. 05） and 24 h and 48 h after treatment,it was significantly lowered（ P〉 0. 05）. The blood lactate concentration of the observation group 24 h and 48 h after treatment was significantly lower than that of the control group（ P 〉0. 05）. The levels of serum IL- 6 and TNF- α before treatment had no statistically significant difference（ P 〉0. 05）and 24 h and 48 h after treatment were significantly lowered（ P 〉0. 05）. The serum levels of IL- 6 and TNF- α 24 h and 48 h after treatment were significantly lower than the control group＇s（ P 〉0. 05）. During treatment,two groups showed no obvious adverse reactions. Conclusion： Shenfu Injection combined with western medicine treatment for septic shock has significant clinical effect,safe and reliable.

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Keyword：:Shenfu Injection Western medicine septic shock effect safety

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  本文关键词：参附注射液联合西药治疗感染性休克临床疗效观察，由笔耕文化传播整理发布。