Ⅰ型干扰素免疫应答作用机制研究进展

发布时间：2017-12-27 08:45

本文关键词：Ⅰ型干扰素免疫应答作用机制研究进展　出处：《微生物学免疫学进展》2014年03期 　论文类型：期刊论文

【摘要】：I型干扰素(IFN-Ⅰ)是机体固有免疫应答的一类重要的细胞因子,具有广谱的抗病毒及抗肿瘤等作用。近年来IFN-Ⅰ成为病毒学、疫苗学及肿瘤学等研究的热点,对干扰素诱导基因(ISGs)的功能研究进一步揭示了其抗病毒以及抗肿瘤的作用机制。麻疹病毒、流感病毒和肠道病毒71型等病毒均可通过与IFN-Ⅰ或其上、下游调节因子结合阻断IFN-Ⅰ信号通路,从而逃逸IFN-Ⅰ的抗病毒作用,这对病毒性疾病的防治是新的挑战。近期研究发现IFN-Ⅰ是疫苗诱导抗体产生的必要信号,同时参与调节T、B细胞的活化过程,在免疫应答过程中发挥关键作用。对IFN-Ⅰ免疫应答作用机制研究进行了综述。
[Abstract]:Type I interferon (IFN- I) is an important cell factor of the body's inherent immune response, which has a broad spectrum of antiviral and anti-tumor effects. In recent years, IFN- I has become a research hotspot in virology, vaccination and oncology. The function of interferon inducible gene (ISGs) has further revealed its antiviral and anti-tumor mechanisms. Measles virus, influenza virus and enterovirus 71 and other viruses can block the IFN- I signaling pathway by escaping from IFN- I or its upstream and downstream regulators, thereby escaping the antiviral effect of IFN- I, which is a new challenge to the prevention and treatment of viral diseases. Recent studies have found that IFN- I is a necessary signal for vaccine induced antibody production, and is also involved in regulating the activation process of T and B cells. It plays a key role in the process of immune response. The research on the mechanism of IFN- I immune response is reviewed.
【作者单位】：卫生部生物技术产品检定方法及标准化重点实验室中国食品药品检定研究院;
【基金】：国家高技术研究发展计划(863计划)项目(2012AA02A402)
【分类号】：R392.11
【正文快照】： 干扰素(Interferon,IFN)是一类高活性多功能的糖蛋白,可以分为I型干扰素(TypeⅠInterferon,IFN-Ⅰ)、II型干扰素(TypeⅡIFN,IFN-Ⅱ)和III型干扰素(TypeⅢIFN,IFN-Ⅲ)三大类,IFN-Ⅰ包括:IFN-α、IFN-β、IFN-ε、IFN-κ、IFN-τ和IFN-ω;IFN-Ⅱ和IFN-Ⅲ分别为IFN-γ和IFN-λ[1-

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